ANGKA KEJADIAN STOMATITIS APTHOSA REKUREN (SAR) DITINJAU DARI FAKTOR ETIOLOGI DI RSGMP FK UNSRAT TAHUN 2014

Stomatitis is inflammation of the mucous lining of any structure padamulut; such as the cheeks, gums (gingivitis), tongue (glossitis) lips, and roof or floor of the mouth. Stomatitis word itself means inflammation of the mouth. Inflammation can be caused by conditions in the mouth (such as poor oral hygiene, poor tooth arrangement), mouth injuries due to hot food or drink, or by conditions that affect the whole body (such as medications, allergic reactions, or infections). This study aims to determine how many patients suffering from recurrent stomatitis afthosa handled in RSGMP FK UNSRAT in 2014. This study was a retrospective descriptive study. The amount of research data obtained is 69 samples and categorized according to gender, age, type of treatment and etiology of the disease. The results showed incidence of recurrent aphthous stomatitis in RSGMP FK UNSRAT distributed as follows: Stomatitis Recurrent Apthosa most common in women with sample trauma predisposing factor of 53%; predisposing factors of stress 21.7%; hormonal imbalance factor of 17.3%; Genetic factor of 11.5% and 1.1% allergic factors.Keywords : Stomatitis Recurrent Apthosa and Etiology factorAbstrak: Stomatitis adalah inflamasi lapisan mukosa dari struktur apa pun padamulut; seperti pipi, gusi (gingivitis), lidah (glositis) bibir, dan atap atau dasar mulut. Kata stomatitis sendiri berarti inflamasi pada mulut. Inflamasi dapat disebabkan oleh kondisi mulut itu sendiri (seperti oral higiene yang buruk, susunan gigi yang buruk), cedera mulut akibat makanan atau minuman panas, atau oleh kondisi yang memengaruhi seluruh tubuh (sepertiobat-obatan, reaksialergi, atauinfeksi). Penelitian ini bertujuan untuk mengetahui berapa banyak pasien yang menderita stomatitis apthosa rekuren yang ditangani di RSGMP FK UNSRAT pada tahun 2014. Jenis penelitian ini merupakan penelitian deskriptif dengan pendekatan retrospektif. Jumlah data penelitian yang didapat yaitu 69 sampel dan di kategorikan sesuai jenis kelamin, usia, jenis perawatan dan etiologi penyakit. Hasil penelitian menunjukkan Angka kejadian stomatitis apthous rekuren di RSGMP FK UNSRAT yang terdistribusi sebagai berikut: Stomatitis Apthosa Rekuren paling banyak terjadi pada sample perempuan dengan faktor predisposisi trauma sebesar 53%; faktor predisposisi stres 21,7%; faktor ketidakseimbangan hormonal 17,3%; factor genetik 11,5% dan faktor alergi sebesar 1,1%.Kata kunci: Stomatitis Apthosa Rekuren, Faktor Etiologi

Immunotoxicology of Food borne Substances: An Overview

The current status of research concerning immunotoxicology of foodborne substances is discussed. Several food additives and bacterial toxins interact directly with cells involved in the immune response and could interfere with natural immunoregulation in the gut. Specialized antibodies produced locally in the gastrointestinal tract help facilitate enzymatic degradation of the substances with which they react by retaining them along the mucous lining; this process is known as immune exclusion. Interference with local production of intestinal antibodies could lead to loss of local immunity and immune exclusion of large, potentially immunogenic proteins. Consequences of chemically induced loss of immune exclusion could include increase in incidence of autoimmune diseases, gastrointestinal allergies, toxigenic diarrheas, and pathogenic invasion through the gut wall. The need for more research is apparent.

A Histochemical Method for the Demonstration of Diphosphopyridine Nucleotide Diaphorase

The present investigation concerning the histochemical demonstration of DPN diaphorase follows the development of a new reagent, Nitro-BT, which has already been used successfully for the cytochemical localization of the succinic dehydrogenase system. The most consistently favorable results were obtained with the lactate-lactic dehydrogenase system buffered at pH 7.4. Using sections of rat kidney and stomach, it was found that the intensity of stain was optimal after 15 minutes incubation at 37°C., conducted aerobically. By appropriate variations in the substrate mixture it was possible to selectively demonstrate the histochemical distribution of certain DPN-linked dehydrogenases in addition to DPN diaphorase. This was made possible by the special distribution of some of these dehydrogenases which distinguished them from one another. Of the dehydrogenases studied the distribution pattern of ß-hydroxybutyric dehydrogenase was the most singular. In the gastric mucosa ß-hydroxybutyric dehydrogenase was restricted to the cells of the mucous lining epithelium and the gland necks; and in the kidney the enzyme was limited to the cells of the proximal convoluted tubule and thick limbs of Henle's loop. In contrast, lactic dehydrogenase like DPN diaphorase was demonstrable in almost all cytologic elements of both the stomach and the kidney.