Comprehensive study of the toothpaste containing fluoride and 67% aqueous sodium bicarbonate solution

Relevance. A wide variety of oral care products is available nowadays. Sometimes aggressive advertising rather than doctor’s advice determines our patients’ choice. In our research, we provide evidence of the clinical use of toothpaste containing fluoride and sodium bicarbonate.Materials and methods. During four weeks, we followed up a group of students who used the toothpaste containing 1400 ppm fluoride and 67% aqueous sodium bicarbonate solution. The clinical, biochemical and microbiological tests and saliva crystallization score assessed the characteristics stated by the manufacturer.Results. The statistically significant correlation between all studied criteria is evidence of the effectiveness of the toothpaste. In addition to the significant remineralization and antiplaque effect, biochemical and microbiological tests confirmed the anti-inflammatory effect of the toothpaste. An immediate cleaning effect was observed after the first brushing as well as in long-term use.Conclusion. Improvement of oral hygiene indices and reduction of periodontal inflammation confirmed the successful result of the comprehensive treatment of chronic gingivitis.

Dinitrophenyl peptides. II. Further studies on the preparation and properties of 2,4-dinitrophenyl glycyl peptides

The study of 2,4-dinitrophenyl peptides has been extended to include the preparation and properties of some further dinitrophenyl dipeptides, namely, the glycyl-l-tryptophan, glycyl-l-proline, glycyl-l-phenylalanine, and glycyl-l-glutamic acid derivatives. Electrophoresis gave a good separation of products, and thin-layer chromatography proved to be a good means of purifying and separating the products. The molar absorbancy varies somewhat in the 350–360, 260–270, and 210–235 mμ, ranges in aqueous sodium bicarbonate solution, is more consistent in 95% ethanol at 344 mμ, and shows some variation in the 255–265 mμ region in 95% ethanol; the infrared absorption spectra have been obtained. The characterization of two dinitrophenyl amino acyl chlorides by conversion into the amides, anilides, and p-toluidides is also reported.