hamster cardiomyopathy
Recently Published Documents


TOTAL DOCUMENTS

29
(FIVE YEARS 0)

H-INDEX

9
(FIVE YEARS 0)

2005 ◽  
Vol 205 (3) ◽  
pp. 397-407 ◽  
Author(s):  
Roberta Fiaccavento ◽  
Felicia Carotenuto ◽  
Marilena Minieri ◽  
Cristina Fantini ◽  
Giancarlo Forte ◽  
...  

2003 ◽  
Vol 81 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Danielle Jacques ◽  
Ghassan Bkaily ◽  
Gaétan Jasmin ◽  
Pedro D'Orléans-Juste ◽  
Mirna Chahine

Recent studies on the heart necrotizing process at the early stages of hamster polymyopathy have led us to believe that this hereditary disease derives from an anomalous transmembrane ion flux due to the presence of slow Na+ channels that contribute to intracellular Na+ accumulation which promote intracellular Ca2+ overload via the Ca2+ influx through the Na+–Ca2+ exchanger. In the present study, we investigated the potential beneficial effect of chronic treatment with a dual L-type Ca2+ and slow Na+ channel blockers isradipine, on the development of necrosis in myopathic hamster hearts. Young cardiomyopathic (CM) hamsters (CMH) were treated with isradipine (0.1 mg·kg–1·day–1) and nifedipine (1 mg·kg–1·day–1) for 4 consecutive weeks. Microscopic assessments were carried out in staged serial paraffin sections of heart ventricles from tissues freshly dissected at autopsy. In comparison with control nontreated hearts, which exhibited numerous necrotic calcific foci, myolytic lesions, and dilated right ventricle, isradipine treatment prevented, in a significant manner, all the above spontaneous pathological changes, while nifedipine had no effect. Our present observations provide evidence for the first time that in vivo treatment with a DHP Ca+ channel blocker, isradipine, is cardioprotective against the development of necrosis in hereditary cardiomyopathy in the hamster. It is possible that the protective effect of isradipine in CMH could be largely due to the indirect blockade of Ca2+ influx through the Na+–Ca2+ exchanger as well as to possible direct blockade of Ca2+ influx through the T-type Ca2+ channel.Key words: isradipine, cardioprotection, hamster cardiomyopathy, slow Na+ channel.


1998 ◽  
Vol 219 (1) ◽  
pp. 48-56
Author(s):  
N. Doliba ◽  
Q. Chang ◽  
N. Doliba ◽  
A. Babsky ◽  
K. Wroblewski ◽  
...  

1995 ◽  
Vol 48 (6) ◽  
pp. 1875-1885 ◽  
Author(s):  
Suhayla Mukaddam-Daher ◽  
Marek Jankowski ◽  
Than-Vinh Dam ◽  
Edmond W. Quillen ◽  
Jolanta Gutkowska

Circulation ◽  
1994 ◽  
Vol 90 (3) ◽  
pp. 1334-1342 ◽  
Author(s):  
G Davison ◽  
C S Hall ◽  
J G Miller ◽  
M Scott ◽  
S A Wickline

1993 ◽  
Vol 125 (2) ◽  
pp. 179-192 ◽  
Author(s):  
Paolo Di Nardo ◽  
Marilena Minieri ◽  
Arnaldo Carbone ◽  
Nicola Maggiano ◽  
Rosella Micheletti ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document