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Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate

2021 ◽  
Vol 19 (11) ◽  
pp. 2448-2455
Author(s):  
Xuanjun Wu ◽  
Hunter McFall-Boegeman ◽  
Zahra Rashidijahanabad ◽  
Kunli Liu ◽  
Christian Pett ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Igg Antibodies ◽  
Mucin 1 ◽  
Peptide Backbone ◽  
Glycoprotein P ◽  
Immunological Evaluation ◽  
Muc1 Glycoprotein

A MUC1 glycopeptide bearing an unnatural β-glycosyl bond between the glycan and the peptide backbone was synthesized. The mimic can induce high levels of IgG antibodies cross-recognizing cancer cells expressing the native MUC1 glycoprotein.

scholarly journals Corrigendum: CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth

2020 ◽  
Vol 11 ◽  
Author(s):  
Ru Zhou ◽  
Mahboubeh Yazdanifar ◽  
Lopamudra Das Roy ◽  
Lynsey M. Whilding ◽  
Artemis Gavrill ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Growth ◽  
Car T Cells ◽  
Car T ◽  
Breast Cancer Growth ◽  
Muc1 Glycoprotein

Abstract 2305: Tumor MUC1 glycoprotein-highly specific CAR T cells control triple-negative breast cancer

2019 ◽  
Author(s):  
Ru Zhou ◽  
Mahboubeh Yazdanifar ◽  
Lopamudra Das Roy ◽  
John Maher ◽  
Pinku Mukherjee
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Car T Cells ◽  
Car T ◽  
Muc1 Glycoprotein

Abstract 2305: Tumor MUC1 glycoprotein-highly specific CAR T cells control triple-negative breast cancer

2019 ◽  
Author(s):  
Ru Zhou ◽  
Mahboubeh Yazdanifar ◽  
Lopamudra Das Roy ◽  
John Maher ◽  
Pinku Mukherjee
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Car T Cells ◽  
Car T ◽  
Muc1 Glycoprotein

Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis

Apmis ◽  
2016 ◽  
Vol 124 (11) ◽  
pp. 913-924 ◽  
Author(s):  
Andreia M. Sousa ◽  
Paul M. Grandgenett ◽  
Leonor David ◽  
Raquel Almeida ◽  
Michael Anthony Hollingsworth ◽  
...  
Keyword(s):  
Muc1 Glycoprotein

Functional Neoglycopeptides: Synthesis and Characterization of a New Class of MUC1 Glycoprotein Models Having Core 2-BasedO-Glycan and Complex-TypeN-Glycan Chains

Biochemistry ◽  
2009 ◽  
Vol 48 (46) ◽  
pp. 11117-11133 ◽  
Author(s):  
Takahiko Matsushita ◽  
Reiko Sadamoto ◽  
Naoki Ohyabu ◽  
Hideki Nakata ◽  
Masataka Fumoto ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
New Class ◽  
Muc1 Glycoprotein

scholarly journals Cover Picture: Synthesis and Biological Evaluation of a Multiantigenic Tn/TF-Containing Glycopeptide Mimic of the Tumor-Related MUC1 Glycoprotein (ChemMedChem 9/2006)

ChemMedChem ◽  
2006 ◽  
Vol 1 (9) ◽  
pp. 909-909
Author(s):  
Gaëlle-Anne Cremer ◽  
Nicole Bureaud ◽  
Véronique Piller ◽  
Horst Kunz ◽  
Friedrich Piller ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Muc1 Glycoprotein

Synthesis and Biological Evaluation of a Multiantigenic Tn/TF-Containing Glycopeptide Mimic of the Tumor-Related MUC1 Glycoprotein

ChemMedChem ◽  
2006 ◽  
Vol 1 (9) ◽  
pp. 965-968 ◽  
Author(s):  
Gaëlle-Anne Cremer ◽  
Nicole Bureaud ◽  
Véronique Piller ◽  
Horst Kunz ◽  
Friedrich Piller ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Muc1 Glycoprotein

scholarly journals Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting molecules

2006 ◽  
Author(s):  
Patricia Burke ◽  
Jeffrey Gregg ◽  
Brandon Bakhtiar ◽  
Laurel Beckett ◽  
Gerald Denardo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Muc1 Glycoprotein ◽  
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