Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin

Extracts ofRuscus aculeatusare rich of deglucoruscin, a spirostanol glycoside, which is able to interact with ATP synthase and modulate its activity.

Steroidal Glycosides from the Underground Parts of Agapanthus inapertus and Their Cytotoxic Activity

Phytochemical investigation of the underground parts of Agapanthus inapertus (Liliaceae) has resulted in the isolation of three new spirostanol glycosides (1, 3, and 4), along with a known spirostanol glycoside (2) and two known spirostanols (5 and 6). The structures of the new glycosides were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells.

A Diosgenin Tetrasaccharide from Cestrum nocturnum

A new monodesmosidic spirostanol glycoside extracted from the fresh leaves of Cestrum nocturnum was identified as spirost-5-ene-3-ol, [3β,25R]-3-O-[{α-L-rhamnopyranosyl-(1→4)- α-L-rhamnopyranosyl-(1→2)}-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside. The name proposed for this saponin is nocturnoside B. The structure elucidation was done on the basis of 1 D and 2 D spectroscopic studies [DEPT. HeteroCOSY, HMBC, COSY-45°, HOHAHA ] and chemical analysis.