Synthesis of a Cholesterylated Compound Containing Carboxyl Functional with PEG2000 Chain for Hepatic Targeting Liposome Ligand

A carboxyl functional cholesterylated compound for hepatic targeting liposome ligand T1 was synthesized. Cholesterol as starting material, after esterification with p-toluenesulfonyl chloride to get cholesterol tosylate M4, then etherification with tetraethylene glycol to get hydroxyl functional M3, M3 react react with methanesulfonyl chloride to get M2, M2 was elongated by reaction with PEG2000 to get M1 and M1 react with succine anhydride get T1. The target compounds afford cholesterylated hepatic targeting liposome ligands.