molecular signaling network
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Physiology ◽  
2019 ◽  
Vol 34 (4) ◽  
pp. 232-239 ◽  
Author(s):  
Scott M. Ebert ◽  
Asma Al-Zougbi ◽  
Sue C. Bodine ◽  
Christopher M. Adams

Skeletal muscle atrophy proceeds through a complex molecular signaling network that is just beginning to be understood. Here, we discuss examples of recently identified molecular mechanisms of muscle atrophy and how they highlight an immense need and opportunity for focused biochemical investigations and further unbiased discovery work.


2019 ◽  
Author(s):  
Eric Czech ◽  
Jeff Hammerbacher

AbstractThe role of many cytokines and transcription factors in the function and development of human T cells has been the subject of extensive research, however much of this work only demonstrates experimental findings for a relatively small portion of the molecular signaling network that enables the plasticity inherent to these cells. We apply recent advancements in methods for weak supervision and transfer learning for natural language models to aid in extracting these individual findings as 283k cell type, cytokine, and transcription factor relations from 64k relevant documents (53k full-text PMC articles and 11k PubMed abstracts). All data, results and source code available athttps://github.com/hammerlab/t-cell-relation-extraction.


2014 ◽  
Vol 122 (12) ◽  
pp. 1261-1270 ◽  
Author(s):  
Qiang Zhang ◽  
Sudin Bhattacharya ◽  
Rory B. Conolly ◽  
Harvey J. Clewell ◽  
Norbert E. Kaminski ◽  
...  

2012 ◽  
Vol 109 (23) ◽  
pp. 9209-9212 ◽  
Author(s):  
D. Breitkreutz ◽  
L. Hlatky ◽  
E. Rietman ◽  
J. A. Tuszynski

Cell ◽  
2008 ◽  
Vol 135 (7) ◽  
pp. 1311-1323 ◽  
Author(s):  
Junichi Hitomi ◽  
Dana E. Christofferson ◽  
Aylwin Ng ◽  
Jianhua Yao ◽  
Alexei Degterev ◽  
...  

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