nmr signal assignment
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Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2497 ◽  
Author(s):  
Zoofishan Zoofishan ◽  
Norbert Kúsz ◽  
Attila Csorba ◽  
Gábor Tóth ◽  
Judit Hajagos-Tóth ◽  
...  

Black mulberry is a widely acknowledged ancient traditional medicine. Its extract and constituents have been reported to exert various bioactivities including antimicrobial, hypotensive, analgesic etc. effects. While black mulberry preparations are also used as antispasmodic agents in folk medicine, no related studies are available on its isolated constituents. Through an extensive chromatographic purification, seven phenolic compounds were isolated from the methanol extract of Morus nigra root bark, including morusin (1), kuwanon U (2), kuwanon E (3), moracin P (4), moracin O (5), albanol A (6), and albanol B (7). A complete NMR signal assignment of moracin P and O was achieved, and related literature errors confusing the identity of moracin derivatives are hereby clarified. Compounds 2, 5 and 7 were identified as strong antispasmodic agents on isolated rat ileum and tracheal smooth muscles, while compound 3, a methoxy derivative of 2, was inactive. Moracin O (5) inhibited the ileal and tracheal smooth muscle contractions with Emax values of 85% and 302 mg, respectively. Those actions were superior as compared with papaverine. Our findings demonstrate that prenylated arylbenzofurans, geranylated flavonoids and Diels-Alder adducts from Morus nigra are valuable antispasmodic agents. Compounds 2, 5 and 7 are suggested as marker compounds for quality control of antispasmodic mulberry preparations. Moracin O (5) is a new lead compound for related drug development initiatives.


2018 ◽  
Vol 56 (9) ◽  
pp. 859-866 ◽  
Author(s):  
Dóra Bogdán ◽  
Rainer Haessner ◽  
Máté Vágvölgyi ◽  
Daniele Passarella ◽  
Attila Hunyadi ◽  
...  

2008 ◽  
Vol 46 (12) ◽  
pp. 1105-1113 ◽  
Author(s):  
Yupeng Li ◽  
Hai Xu ◽  
Linyan Wu ◽  
Feng He ◽  
Fangzhong Shen ◽  
...  

2005 ◽  
Vol 136 (9) ◽  
pp. 1645-1649 ◽  
Author(s):  
Christoph Seger ◽  
Sonja Sturm ◽  
Ernst Haslinger ◽  
Hermann Stuppner

2005 ◽  
Vol 43 (6) ◽  
pp. 489-491 ◽  
Author(s):  
Christoph Seger ◽  
Sonja Sturm ◽  
Maria-Elisabeth Mair ◽  
Ernst P. Ellmerer ◽  
Hermann Stuppner

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