The theory of dysbiosis (dysbacteriosis)

This review article presents definitions of intestinal dysbiosis, main characteristic of normal gastro-intestinal biocenosis, classification of eubiocenosis, data on mucosal and luminal microflora, its functions and their regulation, peculiarities of colon and small intestinal dysbiosis, its classification, criteria for virulence of opportunistic microflora. Debatable terminological issues are considered. Modern methods of diagnostics of colon and small intestinal dysbiosis are described with reference to its clinical manifestations, such as antibiotic-associated diarrhea and pseudomembraneous colitis. New hypotheses of microflora phylogenetic core and symbiotic digestion are discussed with special reference to their rationale and prospects of further studies.

Coexistence of adenocarcinoma colon with pseudomembraneous colitis

We report a 62 year old man who had coexistence of pseudomembraneous colitis and adenocarcinoma sigmoid colon in the absence of any antibiotic therapy. This is the first report of coexistence of both these conditions in the same patient.

Evidence that Clostridium difficile TcdC Is a Membrane-Associated Protein

ABSTRACT Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.