Characterization of protease producing fungi Aspergillus funiculosus and A. tamarii, and their proteases

Two Aspergillus spp. namely A. funiculosus (Za) and A tamarii (Zc) were isolated, purified, identified and studied for their protease activity under some selected environmental condition and nutritional factors. The strains showed the maximal activity of protease after 5 days (Za) and 6 days (Zc) of incubation at 27ºC in a medium containing peptone as nitrogen source with pH 5.0. Isolate Za showed highest protease activity in the presence of fructose as carbon source, at 35 °C, with pH 6.0 and 2.5% casien as substrate concentration. Where as for Zc it was starch as carbon source, temperature 40 °C, with pH 7.0 and 2% casien ,the isolate showed highest enzyme activity. DOI: http://dx.doi.org/10.3329/cujbs.v4i1.13390 The Chittagong Univ. J. B. Sci.,Vol. 4(1&2):91-98, 2009

Synthesis and Antimicrobial Evaluation of Some Thiazole Derivatives

Reaction of 2-amino-4-phenylthiazole with various aromatic aldehydes afforded 2-arylideneamino-4-phenylthiazoles. On the other hand treatment of 2-amino-4-phenylthiazole with several acyl halides furnished N-(thiazol-2-yl)-amides. The synthesized compounds have been screened for their antimicrobial activity against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Shigella dysenteriae, Salmonella typhi, Pseudomonous sp. bacteria and Aspergillus niger, Penicillium notatum, Aspergillus funiculosus, Collectrichum corchori Ikata (Yoshida) and Curvularia lunata fungi respectively. Some of the synthesized compounds exhibited pronounced antimicrobial activities.Keywords: Aminothiazole; Arylideneaminothizole; N-(Thiazol-2-yl)-amide; Antimicrobial activity.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i1.5419 J. Sci. Res. 3 (1), 111-119 (2011)