st3gal iii
Recently Published Documents


TOTAL DOCUMENTS

17
(FIVE YEARS 0)

H-INDEX

11
(FIVE YEARS 0)

2016 ◽  
Vol 36 (6) ◽  
pp. 3317-3324 ◽  
Author(s):  
Hong-Xia Cui ◽  
Honglan Wang ◽  
Yuchun Wang ◽  
Juan Song ◽  
Hua Tian ◽  
...  

2014 ◽  
Vol 133 (1) ◽  
pp. 240-247.e3 ◽  
Author(s):  
Takumi Kiwamoto ◽  
Mary E. Brummet ◽  
Fan Wu ◽  
Mary G. Motari ◽  
David F. Smith ◽  
...  

2013 ◽  
Vol 37 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Fei Zhou ◽  
Liancheng Cui ◽  
Zhiqiang Huang ◽  
Shuang Tong ◽  
Meng Yu ◽  
...  

2013 ◽  
Vol 190 (12) ◽  
pp. 5939-5948 ◽  
Author(s):  
Maho Suzukawa ◽  
Marina Miller ◽  
Peter Rosenthal ◽  
Jae Youn Cho ◽  
Taylor A. Doherty ◽  
...  
Keyword(s):  

2013 ◽  
Vol 131 (2) ◽  
pp. AB238 ◽  
Author(s):  
Takumi Kiwamoto ◽  
Mary E. Brummet ◽  
Mary Motari ◽  
Ronald Schnaar ◽  
Zhou Zhu ◽  
...  

2012 ◽  
Vol 23 (18) ◽  
pp. 3636-3646 ◽  
Author(s):  
Di Mo ◽  
Simone A. Costa ◽  
Gudrun Ihrke ◽  
Robert T. Youker ◽  
Nuria Pastor-Soler ◽  
...  

The sialomucin endolyn is implicated in adhesion, migration, and differentiation of various cell types. Along rat kidney tubules, endolyn is variously localized to the apical surface and endosomal/lysosomal compartments. Apical delivery of newly synthesized rat endolyn predominates over direct lysosomal delivery in polarized Madin–Darby canine kidney cells. Apical sorting depends on terminal processing of a subset of lumenal N-glycans. Here we dissect the requirements of N-glycan processing for apical targeting and investigate the underlying mechanism. Modulation of glycan branching and subsequent polylactosamine elongation by knockdown of N-acetylglucosaminyltransferase III or V had no effect on apical delivery of endolyn. In contrast, combined but not individual knockdown of sialyltransferases ST3Gal-III, ST3Gal-IV, and ST6Gal-I, which together are responsible for addition of α2,3- and α2,6-linked sialic acids on N-glycans, dramatically decreased endolyn surface polarity. Endolyn synthesized in the presence of kifunensine, which blocks terminal N-glycan processing, reduced its interaction with several recombinant canine galectins, and knockdown of galectin-9 (but not galectin-3, -4, or -8) selectively disrupted endolyn polarity. Our data suggest that sialylation enables recognition of endolyn by galectin-9 to mediate efficient apical sorting. They raise the intriguing possibility that changes in glycosyltransferase expression patterns and/or galectin-9 distribution may acutely modulate endolyn trafficking in the kidney.


PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12524 ◽  
Author(s):  
Marta Pérez-Garay ◽  
Beatriz Arteta ◽  
Lluís Pagès ◽  
Rafael de Llorens ◽  
Carme de Bolòs ◽  
...  

2004 ◽  
Vol 23 (1) ◽  
pp. 1-26 ◽  
Author(s):  
Oliver Schwardt ◽  
Gan‐Pan Gao ◽  
Tamara Visekruna ◽  
Said Rabbani ◽  
Ernst Gassmann ◽  
...  

2003 ◽  
Vol 18 (2) ◽  
pp. 116-122 ◽  
Author(s):  
M. Hebbar ◽  
M.-A. Krzewinski-Recchi ◽  
L. Hornez ◽  
A. Verdière ◽  
A. Harduin-Lepers ◽  
...  

Aims and Background A crucial step in the metastatic process is the interaction between the endothelial molecule E-selectin and its tumoral ligands sialyl-Lewisx and sialyl-Lewisa. Sialyltranferases are involved in the biosynthesis of these ligands. The aim of this study was to assess the prognostic value of tumoral sialyltransferase expression and of circulating soluble E-selectin (sE-selectin) in node-negative breast cancer patients. Methods Using a multiplex RT-PCR method, we measured the expression of five sialyltransferases (ST3Gal III, ST6Gal I, ST3Gal IV, ST3Gal I and ST3Gal II) in tumors of 135 surgically treated node-negative breast cancer patients. Circulating sE-selectin concentrations were measured by an ELISA method prior to surgery. We also analyzed tumor size, histoprognostic grading and steroid hormone receptor status. Results The median follow-up was 7.5 years. Expression of estrogen receptors was associated with a good prognosis for relapse-free survival in univariate analysis. A high ST3Gal III/ST6Gal I ratio and a high sE-selectin concentration were associated with a bad prognosis for relapse-free survival and overall survival in univariate and multivariate analysis. Conclusion In the present study, tumoral sialyltransferase expression and circulating sE-selectin concentrations had prognostic value in patients with node-negative breast cancer. This result provides further evidence for the important role of these agents in the metastatic process.


Sign in / Sign up

Export Citation Format

Share Document