EFFECT OF MURCHHIT TILA TAILA UTTARBASTI IN MANAGEMENT OF URETHRAL STRICTURE - A CASE STUDY

In Geriatric patients, urological problems like dribbling micturition, burning micturition, dysuria etc. are commonly seen due to Urethral Stricture, BPH, Chronic urinary tract infection, Urinary Incontinence, Over-active bladder etc. In this study, we will discuss the effect of the Ayurvedic Panchkarma Procedure i.e., Uttarbasti in Urethral Stricture. Urethral Stricture involves scarring that narrows the tube that carries urine out of the body mostly due to STD’s, Catheterisation, straddle injury to the perineum. Newer Surgical Techniques like Urethral Dilatation, DVIU, Ure- throplasty etc are used but they are painful, expensive & has recurrences. In Ayurvedic literature, Mutra mar- gasankoch and Mutrotsanga are an entity that can be closely related to urethral stricture which is described by Acharya Sushruta in Uttartantra. In this case study, a 45-year-old male patient suffering from LUTS Came to Shalya OPD undergone repeated urethral dilatations but was unrelieved. So, after clinical evaluation & Investiga- tions, the case was diagnosed as Urethral Stricture & treated with Uttarbasti. In this case study, Murchhit Tila Taila for the Uttarbasti procedure was used. After the Procedure results were evaluated & the results are satisfying. Keywords: Uttarbasti, Murchhit Tila Taila, Urethral Stricture

Effectiveness of Unani regimen in management of over active bladder: An open labelled, single arm clinical study

Purpose: To study the efficacy of Unani pharmacopoeial formulations viz Jawarish Zarooni, Majoon Kundur and Arq e Badiyaan as a treatment regimen in patients of overactive bladder and evaluate its effect on their quality of life. Materials and Method: This open labeled, single arm clinical study was conducted at Regional Research Institute of Unani Medicine (RRIUM), Srinagar. Patients fulfilling the inclusion criteria were enrolled in the study after signing the informed consent form. Jawarish Zarooni and Arq e Badiyaan were prescribed orally in the dosage of 7g and 30 ml respectively twice a day along with 7g single oral dose of Majoon Kundur. The duration of treatment was for 82 days. The patients were followed up on first, fourth, eighth and twelfth week. The results were expressed as Mean ± SEM. Symptomatic relief was assessed as percentage change in terms of presence of any symptom at baseline and at 82nd day. Results: Of the 36 patients enrolled 31 patients completed the study. The study demonstrated highly significant results (p<0.001) for nocturia and QOL as measured by patients perception of bladder control (PPBC), urinary incontinence and daytime micturation whereas very significant results were observed (p<0.01) for urgency. Conclusions: The Unani regimen was highly effective in managing the symptoms of OAB as the regimen has an array of phyto-constituents which demonstrated muscuranic antagonism, Ca2+ channel blocking, K channel opening, neuro-protection, neuro-toning and anxiety relieving properties. About 50% of the ingredients of the regimen were Ca2+ blockers. The synergism of these phyto-constituents probably made Ca2+ blockers effective in OAB. Keywords: Over Active Bladder, Ca2+ blocker, antimuscuranics

Role of Trospium chloride and tamsulosin therapy for treating patients with symptoms of over-active bladder related to benign prostatic enlargement

To assess the benefit and safety of composite therapy (Tamsulosin and Trospium drugs) in treating benign prostatic enlargement complain, mainly overactive urinary bladder symptoms. OBJECTIVE: The study has been designed to estimate the benefit and safety of Trospium and Tamsulosin in processing of symptoms of excessive bladder and benign prostate hyperplasia (BPH). Patients and Methods: Prospective clinical trial study conducted at Al-Diwaniya teaching hospitals and private clinics from march 2016 to march 2017, to patients BPH and bothersome symptoms. 60 patients were treated with Tamsulocin and 60 patients were treated by Tamsulocin and Trospium. RESULTS: Median scores of IPSS, OABSS, and QOL proved no big difference between two study sets before staring treatment (P = 0.544), (P = 0.287) , (P = 0.668) consecutively. After one month, both treatments led to a big reduction in IPSS, OABSS median score; (P < 0.001), (P < 0.001). Following three months, both treatments resulted in significant reduction in IPSS (P < 0.001), OABSS (P < 0.001), QOL result, (P < 0.001) consecutively. Conclusion: These results suggest which treatment with Trospium and tamsulosin therapy provides benefit for men with natural - Syndrome of the acute urinary tract and benign enlarged prostate.