Synthesis, characterization, and antibacterial studies of pipemidic acid metal complexes

Background Pipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed. Results The compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis. Conclusion The results suggested oxygen atoms present at carbonyl and carboxylic group render the bidentate6 property to the pipemidic acid. The antimicrobial activity of the compounds was determined by the disk diffusion method, and both standard and complexes show no antibacterial activity against the clinical isolates.

Essential and trace elements status in the indigenous Ethiopian tuber crops

The objective of the study is multi elemental analysis of four indigenous Ethiopian tuber crops using instrumental neutron activation analysis (INAA) technique in order to get scientific evidences about the status of essential, trace and non-essential elemental compositions. The samples were collected from Southern and South-western parts of Ethiopia. The irradiation and measurement were performed by using irradiation and counting facilities of the Nigeria Nuclear Reactor-1 (NIRR-1) and a HPGe detector setup at the Centre for Energy Research and Training (CERT), Ahmadu Bello University (ABU), Zaria, Nigeria. A total of 17 elements were determined at various concentration levels. The highest concentrations of K, Mg, Mn and Zn were found in Colocasia esculenta (L.) Schott, whereas; the concentrations of essential and trace elements; Ca, K, Mg, Na, Cl, Mn, and Zn were found to be high in the native Coccinia abyssinica (Lam.) Cogn tuber. The estimated daily intake values of the constituent elements from the consumption of these crops are below upper tolerable limits set by international organizations such as WHO and FAO.