Pharmacological Modeling and Study for Antidiabetic Activity of Praecitrullus fistulosus Leaves Extracts

Phytochemical and pharmacological investigations of leaves of Praecitrullus fistulosus for the antidiabetic activity have been done in our research work encompassed in depth and systematic screening of plant leaves and further extraction, characterization and bioevaluation. The research was envisaged for antidiabetic activity of different extracts procured by successive extraction methods and to find out or isolate the most possible active compounds from the active extracts showing the best activity. The antidiabetic activity of all extracts has been evaluated by STZ induced diabetes. The isolated compounds have been evaluated by in-vitro and in-vivo models. The alcohol soluble extractives values were found to be higher than water soluble extractive value. Alcohol being a moderately non polar solvent, able to extract polar and non-polar components yields higher extractive value. The ethanol extract shows significant enhancement in glucose tolerance in glucose fed hyperglycemic normal rats and produced a marked decrease in blood glucose levels at 200 mg/kg and 400 mg/kg body weight in streptozotocin-diabetic rats after 21 days treatment. Keywords: Praecitrullus fistulosus, Streptozotocin and Glibenclamide, diabetes, Pharmacological Evaluation

Potential Emphasis of Formulated Herbal Cream on Wound Healing

Aim: The present study was to formulate and evaluate the herbal cream comprising extracts of different medicinal plants. Experimental: The aqueous extract of all selected plants (Chenopodium album, Coccinia indica, Momordica dioica, Praecitrullus fistulosus and Trichosanthes dioica) were prepared by successive solvent extraction using soxhlet apparatus. Topical herbal cream was formulate and examined on different parameters like colour, consistency, pH, viscosity, spreadability and stability. Pharmacological evaluation of formulated herbal cream was done with excision and incision wound models. Results and Conclusion: Based on the resultant findings obtained from the different evaluation parameters, it can be concluded that prepared herbal formulation was stable and safe to use in wound healing activity.

COMPARATIVE STUDY OF CUCURBITACEAE MEDICINAL PLANTS FOR PHYSICOCHEMICAL PARAMETERS

Modern research tool for evaluation of plant drugs are available today but physicochemical method is the one simplest and reasonable method for the assessment of quality and purity of crude plant materials. With the aim of drawing the physicochemical parameters of Cucurbitaceae family, the present study deals with leaves of all the selected Coccinia indica, Momordica dioica, Praecitrullus fistulosus, Trichosanthes dioica medicinal plants. The Obtained information will be used for further help in identifying the crude drug as potent therapeutic agents and assist in standardization for excellence and clarity. Keywords: Physicochemical, Ash, Cucurbitaceae, Leaves