Resarch of Monte-Carlo Simulation in Grain Growth

This paper is produced after writing code for doing Monte Carlo simulations of a single type and use the model to study the self-assembly of co-polymers confined to a surface. A great interest has been aroused in the field of Monte Carlo simulation in material science since then. The Monte Carlo algorithm for single-phase normal grain growth is realized which can simulate and observe the current development of the microstructure of large grains in three dimensions. And this study will go through both two- and three-dimension Monte Carlo simulation in grain growth with a brief introduction of the methodology about this. At last, an enormous potential of the Monte Carlo simulation could be spotted in material field and the future material analysis will rely more on computational science due to the powerful computing power.

Ionic liquid-functionalized graphene quantum dot-bonded silica as multi-mode HPLC stationary phase with enhanced selectivity for acid compounds

A novel IL/GQD/SiO2 stationary phase for reversed-phase/normal-phase/ionic exchange and hydrophilic interaction liquid chromatography.

Analysis of Risk Factors for Breast Cancer Decision Support System in Egypt

Breast cancer is the most common form of cancer among women. A risk factor is anything that influences the possibility of obtaining a disease as cancer. The goal of this study is creating economic method for the early detection of breast cancer using risk factors. Two approaches were followed by applying classification techniques. In the first approach, benign, malignant and normal were classified. The second approach comprised two phases. In the first phase, normal and tumor cases were detected, then in the second phase benign and malignant cases were detected. Risk factors were ranked by two different feature selection methods. The best result accuracy of the first phase of the second approach was 96.7%. This could help in the detection of normal and tumor cases without mammography giving a fast diagnosing result, training of non-expert doctors and reducing mammography harms and false diagnosis of inexperienced doctors.

Monte Carlo Simulation of Normal Grain Growth in Three Dimensions

A Monte Carlo algorithm for single-phase normal grain growth has been implemented, which allows one to simulate and observe the temporal development of large grain microstructures in three dimensions. The relaxation process to the self-similar coarsening regime has been studied by following the temporal development of quantities like the average grain size, the standard deviation of the grain sizes and topological correlations.

WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption

No defects related to deficiency of the Wiskott-Aldrich Syndrome protein (WASp) have been described in osteoclasts. Here we show that there are significant morphologic and functional abnormalities. WASp-null cells spread over a much larger surface area and are highly polykaryotic. In their migratory phase, normal cells assemble clusters of podosomes behind their leading edges, whereas during the bone resorptive phase multiple podosomes are densely aggregated in well-defined actin rings forming the sealing zone. In comparison, WASp-null osteoclasts in either phase are markedly depleted of podosomes. On bone surfaces, this results in a failure to form actin rings at sealing zones. Complementation of WASp-null osteoclasts with an enhanced green fluorescent protein (eGFP)-WASp fusion protein restores normal cytoarchitecture. These structural disturbances translate into abnormal patterns of bone resorption both in vitro on bone slices and in vivo. Although physiologic steady-state levels of bone resorption are maintained, a major impairment is observed when WASp-null animals are exposed to a resorptive challenge. Our results provide clear evidence that WASp is a critical component of podosomes in osteoclasts and indicate a nonredundant role for WASp in the dynamic organization of these actin structures during bone resorption. (Blood. 2004;103:3552-3561)