Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.

Delayed Stochastic Biochemical Reactions Reconstruction Based on Additive Reaction Model

Stochastic dynamics and delayed time of biochemical reactions play an important role in the biological networks such as gene regulatory and metabolic networks. This paper presents a new model, called additive reaction model (ARM), to capture the stochastic dynamical and delayed behavior. The new evolutionary strategy is used to search the optimal biochemical model, in which genetic algorithm (GA) and particle swarm optimization (PSO) are employed to evolve the architecture and parameters of biochemical reactions, respectively. The results reveal that the delayed biochemical reaction modeling problems could be solved effectively and efficiently using our proposed new model and new evolutionary strategy.