MXene-based hybrid system exhibits excellent synergistic antibiosis

MXene are a group of inorganic two-dimensional (2D) nanomaterial, and have raised significant interests in biomedical areas. Ti3C2Tx, as an important member of MXene family, is widely studied because of its biodegradability and low-cytotoxicity. However, their single antibacterial mechanism and poor stability in aqueous solution need to be improved, especially for the antimicrobial applications. In this work, a MXene-based hybrid antibacterial system (M-HAS) was developed and its synergistic antibacterial activity was investigated. In the M-HAS, 2D few-layer Ti3C2Tx (FL-Ti3C2Tx) was modified with hydrophilic polymers and thereby used as carriers for silver nanoparticles (Ag NPs). By assembling these two substrates, photodynamic performance of the prepared system is significantly improved with a large amount of reactive oxygen species (ROS) production under 660 nm laser. Antibacterial effects of the M-HAS are enhanced by over 4 times with irradiation. In another word, the developed hybrid system displays excellent photodynamic antibacterial synergistic properties. This work takes full advantage of the photodynamic properties of every component in the MAS to achieve efficient antibacterial activity and proposes an innovative approach to develop the 2D FL-Ti3C2Tx-based antibacterial platform.

Investigating the Synergistic Antibacterial Activity of Epiphytic Bacterial Polyketides and Biopolymer Alginates from Marine Microalgae

The objective was framed to analyse the synergistic antibacterial activity and woundhealing ability of the developed polyketide-alginate polymers. Alginates were extracted from a brown seaweed Padina tetrastromatica and used as a synergistic compound along with bacterial polyketides. Polyketides and alginate polymer combinations were used against test bacteria to determine the synergistic antibacterial activity. A novel wound-healing film was developed using polyketide and alginates with synergistic concentrations and its degradability and wound-healing ability was investigated. The findings in the present research showed most significantly that, Staphylococcus aureus showed complete synergy with the mean MIC value of 0.03 μg/ml and with best FIC value of 0.24 (p<0.5). Degradation of developed films revealed that more moisture leads to more release of antibacterial alginate content at the wound site and hence more degradation. This was evident from the FESEM analysis. In vitro wound-healing assay revealed that the developed polyketide-alginate polymers exhibited cell migration and proliferation after 24th hour of incubation at 370C indicating the wound-healing abilities. Hence, it can be concluded that the biochemical compounds present in the developed polyketide-alginate polymers are considered highly significant in treating any types of wounds.