Eccrine sweat glands are widely distributed throughout the body and regulate body temperature in respond to cholinergic stimuli. Eccrine sweat gland carcinomas are rare and were first described by Cornil in 1865. Their incidence is 1% of all cutaneous malignancies, and the wide range of histological appearances and their similarity to metastatic carcinomas have generated uncertainties and controversies for many years regarding its diagnosis, biological behavior, and treatment. We present the case of a patient with eccrine duct carcinoma of the knee that recurred four years after her first excision. Key words: case report, eccrine sweat glands, eccrine duct carcinoma, cutaneous malignancies