Quality Assessment for National Libraries

National libraries as well as any other progressive institutions have to assess the results of their performance. Depending on the type, functions, structure, areas of activities, organizational and financial methods, any national library can test wide sets of performance indicators consistent with its mission. Those indicators may differ from the indicators being tested by other national libraries. Quite often national libraries can also use additional indicators if financial/sponsoring organizations or target user groups etc. require this.The paper considers the methods and procedures for measuring quantitative indicators of national libraries’ performance according to the new international standard ISO 21248:2019 “Information and documentation: Quality assessment for national libraries”, which is partially based upon the ISO 11620:2008 standard “Information and documentation. Library performance indicators”. The author presents specific examples for calculating indicators using formulas and detailed description of steps for calculation of indicators depending on the library mission and goals. Along with qualitative indicators, the new standard recommends to use qualitative indicators to assess the impact of national libraries not only on their users, but also on society as a whole. In recent years, libraries have developed and probated methods to justify their importance. One of those methods is user surveying by means of special questionnaires made on the basis of ISO 16439:2014 standard “Information and documentation. Methods and procedures for assessing the impact of libraries” and circulated by libraries among their users to educe and differentiate interests of different user groups to provide them with subsequent target service.

Diversion of Attention Leads to Conflict between Concurrently Attended Stimuli, Not Delayed Orienting to the Object of Interest

The control processes that guide attention to a visual-search target can result in the selection of an irrelevant object with similar features (a distractor). Once attention is captured by such a distractor, search for a subsequent target is momentarily impaired if the two stimuli appear at different locations. The textbook explanation for this impairment is based on the notion of an indivisible focus of attention that moves to the distractor, illuminates a nontarget that subsequently appears at that location, and then moves to the target once the nontarget is rejected. Here, we show that such delayed orienting to the target does not underlie the behavioral cost of distraction. Observers identified a color-defined target appearing within the second of two stimulus arrays. The first array contained irrelevant items, including one that shared the target's color. ERPs were examined to test two predictions stemming from the textbook serial-orienting hypothesis. Namely, when the target and distractor appear at different locations, (1) the target should elicit delayed selection activity relative to same-location trials, and (2) the nontarget search item appearing at the distractor location should elicit selection activity that precedes selection activity tied to the target. Here, the posterior contralateral N2 component was used to track selection of each of these search-array items and the previous distractor. The results supported neither prediction above, thereby disconfirming the serial-orienting hypothesis. Overall, the results show that the behavioral costs of distraction are caused by perceptual and postperceptual competition between concurrently attended target and nontarget stimuli.

From “satisfaction of search” to “subsequent search misses”: a review of multiple-target search errors across radiology and cognitive science

For over 50 years, the satisfaction of search effect has been studied within the field of radiology. Defined as a decrease in detection rates for a subsequent target when an initial target is found within the image, these multiple target errors are known to underlie errors of omission (e.g., a radiologist is more likely to miss an abnormality if another abnormality is identified). More recently, they have also been found to underlie lab-based search errors in cognitive science experiments (e.g., an observer is more likely to miss a target ‘T’ if a different target ‘T’ was detected). This phenomenon was renamed the subsequent search miss (SSM) effect in cognitive science. Here we review the SSM literature in both radiology and cognitive science and discuss: (1) the current SSM theories (i.e., satisfaction, perceptual set, and resource depletion theories), (2) the eye movement errors that underlie the SSM effect, (3) the existing efforts tested to alleviate SSM errors, and (4) the evolution of methodologies and analyses used when calculating the SSM effect. Finally, we present the attentional template theory, a novel mechanistic explanation for SSM errors, which ties together our current understanding of SSM errors and the attentional template literature.

Improving SAR Target Recognition Performance Using Multiple Preprocessing Techniques

The synthetic aperture radar (SAR) image preprocessing techniques and their impact on target recognition performance are researched. The performance of SAR target recognition is improved by composing a variety of preprocessing techniques. The preprocessing techniques achieve the effects of suppressing background redundancy and enhancing target characteristics by processing the size and gray distribution of the original SAR image, thereby improving the subsequent target recognition performance. In this study, image cropping, target segmentation, and image enhancement algorithms are used to preprocess the original SAR image, and the target recognition performance is effectively improved by combining the above three preprocessing techniques. On the basis of image enhancement, the monogenic signal is used for feature extraction and then the sparse representation-based classification (SRC) is used to complete the decision. The experiments are conveyed on the moving and stationary target acquisition and recognition (MSTAR) dataset, and the results prove that the combination of multiple preprocessing techniques can effectively improve the SAR target recognition performance.

Automatic capture of attention by flicker

Visual motion captures attention, but little is known about the automaticity of these effects. Here, we tested if deviant flicker frequencies, as one form of motion, automatically capture attention. Observers searched for a vertical target among tilted distractors. Prior to the target display, a cue array of sinusoidally modulating (flickering) annuli, each surrounding one location of the subsequent target(-plus-distractors) display was presented for variable durations. Annuli either flickered all at 1 Hz (neutral condition, no-singleton cue), or a single annulus flickered at a unique frequency of 5 Hz, 10 Hz, or 15 Hz. The location of this singleton-frequency cue was uncorrelated with target location. Thus, we could measure benefits (target at cued location) and costs (target ≠ cued location) for cues of different frequencies and durations. The results showed that deviant flicker frequencies capture attention, as we observed benefits and costs, falsifying that nonspatial filtering accounted for the cueing effect. In line with automatic capture, cueing was effective in singleton (Experiment 1) and nonsingleton search tasks (Experiment 2), and is thus not dependent on (“top-down”) singleton detection mode. Moreover, analysis of results ruled out trial-by-trial “swapping” of flicker frequencies from preceding target to subsequent distractor locations. Results also revealed increasing cueing effects with higher cue flicker frequency and longer duration. This indicates a significantly longer period of automatic capture by sinusoidal flicker than the typical inhibition of return observed around 250 ms after the onset of uninformative static or single-transient cues.

Prioritization of antimicrobial targets by CRISPR-based oligo recombineering

SummaryNucleophilic amino acids are important in covalent drug development yet underutilized as antimicrobial targets. Over recent years, several chemoproteomic technologies have been developed to mine chemically-accessible residues via their intrinsic reactivity toward electrophilic probes. However, these approaches cannot discern which reactive sites contribute to protein function and should therefore be prioritized for drug discovery. To address this, we have developed a CRISPR-based Oligo Recombineering (CORe) platform to systematically prioritize reactive amino acids according to their contribution to protein function. Our approach directly couples protein sequence and function with biological fitness. Here, we profile the reactivity of >1,000 cysteines on ~700 proteins in the eukaryotic pathogen Toxoplasma gondii and prioritize functional sites using CORe. We competitively compared the fitness effect of 370 codon switches at 74 cysteines and identify functional sites in a diverse range of proteins. In our proof of concept, CORe performed >800 times faster than a standard genetic workflow. Reactive cysteines decorating the ribosome were found to be critical for parasite growth, with subsequent target-based screening validating the apicomplexan translation machinery as a target for covalent ligand development. CORe is system-agnostic, and supports expedient identification, functional prioritization, and rational targeting of reactive sites in a wide range of organisms and diseases.

Acquisition and Use of ‘Priors’ in Autism: Typical in Deciding Where to Look, Atypical in Deciding What Is There

Individuals with Autism Spectrum Disorder (ASD) are thought to under-rely on prior knowledge in perceptual decision-making. This study examined whether this applies to decisions of attention allocation, of relevance for ‘predictive-coding’ accounts of ASD. In a visual search task, a salient but task-irrelevant distractor appeared with higher probability in one display half. Individuals with ASD learned to avoid ‘attentional capture’ by distractors in the probable region as effectively as control participants—indicating typical priors for deploying attention. However, capture by a ‘surprising’ distractor at an unlikely location led to greatly slowed identification of a subsequent target at that location—indicating that individuals with ASD attempt to control surprise (unexpected attentional capture) by over-regulating parameters in post-selective decision-making.

A Case of Complete Double Layer Stents Fracture in Right Coronary Artery

Background: Coronary stent fracture is a rare and serious complication, because it is closely related to restenosis, stent thrombosis, and subsequent target lesion revascularization. We describe the fracture of a double layer of stents in a patient with recurrent acute inferior myocardial infarction. Case presentation: A 67-year-old man was hospitalized for untypical chest pain, with prior stents implantation twice in proximal of right coronary artery due to acute and recurrent myocardial infarction, complete stent fracture was revealed in right coronary artery by angiography and optical coherence tomography. Conservative therapy was chosen, as enough lumen area was observed without aneurysm. No recurrent chest discomfort was reported in 3 month after discharge.Conclusion: Our case describes complete double layer of stents fracture in right coronary artery, the patient get better prognosis through conservative treatment.

Looming cue sounds

Studies suggest a prioritization in the neural processing of looming sounds. A little explored issue is the relationship between this perceptual bias and the orienting and alerting auditory attention networks. The present study investigated the effect of a warning sound on the speed of response to a subsequent target sound (Experiment 1) and a possible influence of this type of cue sound on the auditory orientation of attention (Experiment 2). The results of the two experiments suggest a significant reduction in the reaction time for a subsequent target sound due to the previous presentation (500 ms) of a looming warning sound. There was no significant effect of the cue sound on auditory attention orientation.

An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output

SummaryWhile precise tuning of gene expression levels is critical for most developmental pathways, the mechanisms by which the transcriptional output of dosage-sensitive molecules is established or modulated by the environment remain poorly understood. Here, we provide a mechanistic framework for how the conserved transcription factor BLMP-1/Blimp1 operates as a pioneer factor to decompact chromatin near its target loci hours before transcriptional activation and by doing so, regulates both the duration and amplitude of subsequent target gene transcription. This priming mechanism is genetically separable from the mechanisms that establish the timing of transcriptional induction and functions to canalize aspects of cell-fate specification, animal size regulation, and molting. A key feature of the BLMP-1-dependent transcriptional priming mechanism is that chromatin decompaction is initially established during embryogenesis and maintained throughout larval development by nutrient sensing. This anticipatory mechanism integrates transcriptional output with environmental conditions and is essential for resuming normal temporal patterning after animals exit nutrient-mediated developmental arrests.