signet cell
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2021 ◽  
Vol 116 (1) ◽  
pp. S1517-S1517
Author(s):  
Stefan Canacevic ◽  
Babiswarup Chandamuri ◽  
Shaminder Gupta

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shotaro Korehisa ◽  
Akira Kabashima ◽  
Michihiro Ichimanda ◽  
Kenji Umeda ◽  
Hidenori Koso ◽  
...  

Abstract Background Skeletal muscle metastasis from gastric cancer is rare and has a poor prognosis. We reported a case of gluteal muscle metastasis with peritoneal dissemination from gastric cancer during postoperative adjuvant chemotherapy. Case presentation A 64-year-old man with gastric cancer underwent distal gastrectomy with D2 lymph node resection. The pathological diagnosis was poorly differentiated adenocarcinoma and signet cell carcinoma, T3N3bM0, Stage IIIC. Metastases were found in all regional lymph nodes, except 11p. The resection margin was negative. S-1 plus docetaxel therapy was administered as postoperative adjuvant chemotherapy. Six month post-operation, the patient presented with right gluteal muscle tenderness and abdominal distension. Computed tomography revealed a solid mass in the right gluteal muscle, a disseminated nodule on the abdominal wall, and massive ascites. Pathological examination of the gluteal muscle revealed signet cell carcinoma, similar to the resected gastric cancer. The tumor was diagnosed as gastric cancer metastases. Ascites cytology was class V. Thereafter, the patient underwent one course of capecitabine plus cisplatin combined with trastuzumab. Radiation therapy was also administered to relieve the pain of gluteal muscle metastasis. However, chemoradiotherapy was ineffective, and the patient died 2 months after the recurrence. Conclusions Skeletal muscle metastasis and peritoneal dissemination during adjuvant chemotherapy indicated a poor prognosis.


2021 ◽  
Vol 05 (02) ◽  
pp. 255-259
Author(s):  
Alkhatib Amani ◽  
Diab Mostafa ◽  
Assaf Mouchira ◽  
AlOmary Abdullah ◽  
Mroue Ahmad ◽  
...  

2020 ◽  
Vol 115 (1) ◽  
pp. S1480-S1481
Author(s):  
Tiago Martins ◽  
Jalaluddin Umar ◽  
David Desilets

2020 ◽  
pp. 107815522092515
Author(s):  
Tugba Basoglu ◽  
Tugba Akin Telli ◽  
Nazim Can Demircan ◽  
Rukiye Arikan ◽  
Ozlem Ercelep ◽  
...  

Background Gastric cancer is rare during pregnancy and often diagnosed at a later stage due to overlapping symptoms of pregnancy. Breast metastasis of gastric cancer is another uncommon entity. We present a rare case of breast metastasis of gastric cancer during pregnancy. Case report A 26-year-old female was diagnosed with gastric cancer at 14 weeks of gestation and underwent total gastrectomy. She rejected adjuvant chemotherapy and continued pregnancy without any follow-up. Cancer recurred in bilateral breasts at 34th week of gestation mimicking primary inflammatory breast cancer. Management and outcome It was difficult to diagnose breast metastasis during pregnancy because of overlapping pregnancy symptoms. Following an unresponsive period to antibiotherapy, a fine needle biopsy on breast was performed and signet cell adenocarcinoma metastasis was determined. We started chemotherapy after delivery. There was a near complete response after first line of chemotherapy. Unfortunately, cancer was relapsed within three months and we started second-line chemotherapy. Discussion To our knowledge, this is the fourth case reported in medical literature of gastric cancer presented with breast metastasis during pregnancy. We will try to draw attention to diagnosis, treatment and different presentation of gastric cancer during pregnancy with review of the literature.


2020 ◽  
Vol 11 (5) ◽  
pp. 135-139
Author(s):  
Mujtaba Mohamed ◽  
Alsadiq Al Hillan ◽  
Eugene Zurkovsky ◽  
Min Zheng ◽  
Arif Asif ◽  
...  

2020 ◽  
Vol 65 (2) ◽  
pp. 148
Author(s):  
Simay Cokgezer ◽  
NilaySengul Samanci ◽  
Mert Bektas ◽  
Nuray Kepil ◽  
FuatHulusi Demirelli

2019 ◽  
Vol 12 (8) ◽  
pp. e225756
Author(s):  
Joseph O’Brien ◽  
Nicholas Jones ◽  
Mark Horrigan ◽  
Ahmed M Al-Kaisey

Pulmonary tumour thrombotic microangiopathy (PTTA) is a rare but lethal cause of pulmonary hypertension (PHT). Its underlying mechanism is believed to be fibrocellular intimal proliferation and microthrombosis. It has been reported in association with gastric adenocarcinoma and breast, pancreatic and lung cancers. The diagnosis is often made on postmortem examination due to the absence of diagnostic criteria and its rare occurrence. We describe the case of a middle-aged man who presented with rapidly progressive PHT. He deteriorated into multiorgan failure despite aggressive medical therapy and died 4 weeks after his initial presentation. A postmortem examination confirmed the diagnosis of PTTA in addition to the finding of signet cell gastric adenocarcinoma. This case highlights the lethal nature of this rare condition, the ongoing challenges in making an antemortem diagnosis, and the importance of postmortem examination in determining the cause of death to provide closure for both, the treating physician and the family.


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