dna purine bases
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scholarly journals Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article

2020 ◽  
Vol 7 (2) ◽  
pp. 20-26
Author(s):  
Dalia A. Shakur ◽  
Suhad F. H. Al-Mugdadi ◽  
Inam S. Arif
Keyword(s):  
Cytotoxic Effect ◽  
Molecular Mechanisms ◽  
Review Article ◽  
Chemotherapeutic Drug ◽  
Immunomodulatory Effects ◽  
Molecular Mechanism Of Action ◽  
Immunomodulatory Properties ◽  
Dna Break ◽  
Dna Purine Bases ◽  
Platinum Analogs

Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.

scholarly journals DFT study of [Pt(Cl)2L] complex (L = rubeanic acid) and its derived compounds with DNA purine bases

2020 ◽  
Vol 530 ◽  
pp. 110646 ◽  
Author(s):  
Amit Kumar ◽  
Gianluca Gatto ◽  
Francesco Delogu ◽  
Luca Pilia
Keyword(s):  
Dft Study ◽  
Purine Bases ◽  
Rubeanic Acid ◽  
Dna Purine Bases

Mechanisms of reactions of Ru(iii)-based drug NAMI-A and its aquated products with DNA purine bases: a DFT study

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113620-113629 ◽  
Author(s):  
Pramod Kumar Shah ◽  
Kanika Bhattacharjee ◽  
Pradeep Kumar Shukla
Keyword(s):  
Density Functional Theory ◽  
Density Functional ◽  
Dft Study ◽  
Functional Theory ◽  
Purine Bases ◽  
Mechanism Of Reaction ◽  
Dna Purine Bases ◽  
Mechanisms Of Reactions

The mechanism of reaction of NAMI-A with guanine has been investigated theoretically using density functional theory.

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