prophylactic lymphadenectomy
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2021 ◽  
Author(s):  
Silvia Sabattini ◽  
Matti Kiupel ◽  
Riccardo Finotello ◽  
Damiano Stefanello ◽  
Eugenio Faroni ◽  
...  

Abstract Background. While lymphadenectomy of metastatic 27 lymph nodes (LNs) has been associated with improved outcome, the clinical utility of prophylactic lymphadenectomy in dogs with stage I cutaneous mast cell tumors (cMCTs) remains a controversial topic. To assess the therapeutic role of lymphadenectomy of uninvolved regional LNs, the long-term outcome of cMCT-bearing dogs with cytologically negative and surgically unresected regional LNs (observation only, OO) was compared with that of dogs with a surgically resected and histologically negative regional LNs (prophylactic regional lymphadenectomy, PRL).Results. A retrospective analysis of 64 dogs with a low-grade, completely resected stage I cMCT was performed: (54.7%) dogs were subjected to OO and 29 (45.3%) underwent PRL. Dogs were monitored for a median of 813 and 763 days in the OO group and PRL group, respectively. The number of dogs undergoing MCT progression was significantly higher in the OO group (P = 0.028) and curve comparison revealed a tendency to a better time to progression in the PRL group (P = 0.058). No significant difference in survival time (P = 0.294) was observed between dogs in the OO and PRL groups.Conclusions. Our results showed that lack of immediate lymphadenectomy was associated with a higher risk for tumor progression. This preliminary judgement, reinforced by the findings that lymphadenectomy was well tolerated in all cases, and that histopathology provides the definitive assessment of the nodal pathological status, may suggest that prophylactic lymphadenectomy is indicated in the management of stage I MCTs. Larger prospective studies are warranted for generating clinical evidence of this latter hypothesis.


Medicine ◽  
2020 ◽  
Vol 99 (9) ◽  
pp. e19128
Author(s):  
Athienne D. M. T. do Nascimento ◽  
Jaqueline D. Pinho ◽  
Antonio Augusto L. Teixeira Júnior ◽  
Joyce S. Larges ◽  
Fabrício M. Soares ◽  
...  

2010 ◽  
Vol 143 (2_suppl) ◽  
pp. P198-P198
Author(s):  
Jin Woong Choi

2010 ◽  
Vol 17 (6) ◽  
pp. 1637-1641 ◽  
Author(s):  
Bon Seok Koo ◽  
Sung-Tae Seo ◽  
Gun-Ho Lee ◽  
Jin-Man Kim ◽  
Eun Chang Choi ◽  
...  

1985 ◽  
Vol 38 (4) ◽  
pp. 319-327 ◽  
Author(s):  
Marilee J. Mead ◽  
S.David Nathanson ◽  
Min Lee ◽  
Edward Peterson

1982 ◽  
Vol 12 (4) ◽  
pp. 244-248 ◽  
Author(s):  
Yoshifumi Kodama ◽  
Tadashi Kano ◽  
Ryuichiro Tamada ◽  
Ryunosuke Kumashiro ◽  
Takeshi Okamura ◽  
...  

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