There is a general consensus in the economic literature that there is a strong correlation between structural changes and economic growth: structural changes are the most significant repercussion of economic growth, but at the same time, in the long run, it's most important factor. Having in mind this fact, the analysis of structural changes and economic growth of the Republic of Serbia is a key research issue on which this paper focuses. In that sense, the paper, based on relevant theoretical knowledge and reference statistics on the movement of basic macroeconomic indicators, monitors and analyzes the effects of applied models of economic growth in the process of structural adjustment of the economy of the Republic of Serbia during the first two decades of the 21st century, in which major, and in some sub periods, specific structural changes took place.