REVIEW ON COMPILATION OF ETHNOPHARMACOLOGICAL PROPERTIES OF BERGENIA CILIATA: THE MEDICINAL HERB OF HIMALAYAS

As mentioned in the texts such as Vedas, Charaka Samhita and Sushruta Samhita, Bergenia ciliata is a known to be the ancient and medicinal plant belonging to the family Saxifragaceae. It can be found as a shrub or an herb, while some are trees or vines. The family includes about 80 genera, 1250 species and has biological properties that are possessed by the different plant parts including antibacterial, antiviral, antioxidant, anti-ulcer, anti-diabetic, analgesic, anti-plasmodial, antitumor, antitussive activity, antineoplastic, diuretic and anti-inflammatory properties. Many of its members grow in rocky places. Bergenia ciliata itself shows that the plant originate between rocks and appears to break them or that it possesses lithotroptic property. It’s different plant parts are reported to have different medicinal properties. There are three species of Bergenia found in India Bergenia ligulata, Bergenia ciliata, Bergenia stracheyi. The rhizomes of these plants are used in the indigenous system of medicines.

Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial

Remifentanil has been used to suppress peri-extubation cough. Palonosetron, a 5-HT3 receptor antagonist, is an effective antiemetic, and 5-HT receptors mediate the cough reflex. We assessed the impact of palonosetron on effect-site concentration (Ce) of remifentanil for preventing emergence cough in females. Forty-five female patients undergoing laparoscopic cholecystectomy randomly received 0.075 mg of palonosetron (n = 21) or normal saline (n = 24) intravenously at the end of surgery. The remifentanil Ce for 50% (EC50) and for 95% (EC95) of patients were estimated via Dixon’s up-and-down method or isotonic regression. Using Dixon’s method, EC50 in the control group (1.33 ± 0.38 ng/mL) was comparable to that of the palonosetron group (1.42 ± 0.75 ng/mL) (p = 0.813). Using isotonic regression, EC50 (83% CIs) and EC95 (95% CIs) did not reveal significant differences between the control and the palonosetron groups (1.17 (0.86–1.43) and 1.90 (1.45–1.96) ng/mL and 0.88 (0.78–1.23) and 2.43 (1.94–2.47) ng/mL, respectively). No difference was found in the remifentanil Ce to suppress emergence cough in the palonosetron group compared with the control group. It may indicate no effect of palonosetron on antitussive activity of remifentanil.

Preliminary investigation of the aqueous leaf extract of Chrysophyllum albidum George Don (Sapotaceae) in laboratory-induced cough

Cough is the most common symptom of respiratory diseases, however, in distressing and severe cases, opioids are effective, but their use has been challenged by side effects such as sedation, constipation; also, by some addictive liability, as well as the compromise of respiratory function. Therefore, there is a dire need for effective antitussives that will override the limitations of the opioids. Chrysophyllum albidum (Linn), family Sapotaceae, and also known as African star apple is primarily a forest tree species with its natural occurrences in diverse ecozones in Uganda, Nigeria and Niger Republic. Across Nigeria, it is known by several local names, for example, as ‘Agbalumo’ in Yoruba, and is generally regarded as a plant with diverse ethno-medicinal uses, including the treatment of cough and asthma. The present study was designed to evaluate possible antitussive activity of Chrysophyllum albidum. Cough was induced in the animals using 25 % ammonium hydroxide- and acetic acid (concentrated), after which the mice were randomized into treatment groups as follows: (Group 1, normal control), 10 mg/kg dextromethorphan (Group 2), 5.7 mg/kg codeine (Group 3), 100, 200 and 400 mg/kg, Chrysophyllum albidum (groups 4, 5 and 6). Cough induction was carried out in an enclosed dessicator for one minute and the number of coughs was, counted and recorded for five minutes. The animals were further exposed at 30, 60, 90 and 120 minutes. The same procedure was repeated for acetic acid-induced cough. Chrysophyllum albidum showed significant antitussive activity (p<0.001) in both ammonium hydroxide and acetic acid-induced cough model. The findings in this study validates the folkloric use of Chrysophyllum albidum in alleviating cough.

CASSIA FISTULA: BOTANY, PHYTOCHEMISTRY AND PHARMACOLOGICAL LEVERAGES-A REVIEW

Cassia fistula Linn. is also called a “golden shower”. It is aboriginal to India, Sri Lanka and diffused in various countries, including Mexico, China, Mauritius, East Africa, South Africa, and West Indies. Plant and its parts, such as bark, fruit, leaves, and seeds, are used traditionally to cure diseases. Traditionally the plant possesses hepatoprotective, antipyretic, anti-inflammatory, leukotriene inhibition, antitussive activity, antioxidant, wound healing, hypo-lipidemia, anticancer, antidiabetic, central nervous system activity, antiulcer, antibacterial, antifertility, larvicidal and ovicidal, antifeedant, laxative, anti-epileptic, antimicrobial, urease inhibition, antifungal, anti-tobacco mosaic virus activities. The review contains botanical information, constituents and pharmacological leverages of the plant. The review draws attention towards the traditional, phytochemical and pharmacological knowledge accessible on Cassia fistula Linn, which would be beneficial for research scholars to develop novel chemical entities. This review article is written after studying most of the journal’s articles, which were published between 1998 to 2019.

STUDY OF POTENTIAL ANTITUSSIVE ACTIVITY OF GLYCYRRHIZA GLABRA GRANULES BY USING A COUGH MODEL INDUCED BY SULPHUR DIOXIDE GAS IN MICE

In respiratory diseases cough is most common symptom. When cough becomes severe, opioids are potent, but they have side effects like sedation, constipation. Therefore, there is a necessary to have effective antitussive formulation, which does not have respiratory depressant activity. The present study was carried out to analysis antitussive activity of Glycyrrhiza glabra L. using a cough model induced by sulphur dioxide gas in experimental mice. The effect of the granules of Glycyrrhiza glabra extract on SO2 gas induced cough in experimental animals have very significant effects at the level of p<0.01 in inhibiting the cough reflex at a dose of 200 mg/kg body weight, in comparison with the control group. Mice were showed an inhibition of 41.17%, in cough on treatment with Glycyrrhiza glabra granules at 60 min experiment. The antitussive activity of the granules was comparable to that of codeine sulphate (10, 15, 20 mg/kg body weight), a standard anti-tussive agent. Codeine sulphate, as a standard drug for suppression of cough, produced 25.29%, 33.33%, 47.13% inhibition in cough at a dose of 10 mg/kg, 15 mg/kg and 20 mg/kg respectively, whereas, codeine sulphate (20 mg/kg) showed maximum 47.13% (p<0.001) inhibition at 60 min of the experiment.

ANTITUSSIVE ACTIVITY ASSAYOF SAGE (LANTANA CAMARA L.)LEAVES BASED ON THE BREATHING PATTERN OF MALE GUINEA PIGS USING ADOBE AUDITION 1.5 PROGRAM

Objective: The present study was aimed to assay antitussive activity of Sage (Lantana camara L.)leavesMethods: Antitussive Assay was conducted based on The Breathing Pattern of Male Guinea Pigs Using Adobe Audition 1.5 Program.Results: Comparison of the frequency of breathing patterns guinea pig groups sage (Lantana camara L.)Â leaves water fraction at a dose of 4.58 mg/kg bw dose of 9.17 mg/kg bw and doses of 18.35 mg/kg bw statistically significantly different results (p<0.05), as well as the ratio of intensity of the breathing pattern of the guinea pig. As for the water extract, significant differences in the frequency comparison guinea pig respiratory pattern is only shown at a dose of 18.35 mg/kg bw on the other side for its intensity did not show significant differences (p<0.05).Conclusion: Ethanol extract of sage leaves in the form of three fractionation (ethyl acetate, n-hexane, and water) can improve the breathing pattern guinea pig cough, especially at a dose of 18.35 mg/kg bw.Â