COMBINATING DERMAL FILLER IN DEPRESSED ACNE SCARS TREATMENT

Acne scars are common sequelae of adolescent acne and have many negative effects on patients. Scars can affect the aesthetics and psychology of patients, limiting social interaction and affecting success in life. The forms of acne scars are very diverse and complex. Each patient can have many scars associated with different degrees. Although there are many methods treatment, successfully treating acne scars is still challenging. Combinating dermal filler with other scar treatments (dermal subcision, laser fractional CO2, RF needle ...) accurately helping improve treatment effectiveness, minimizes side effects or complications due to treatment. Objective of the review is to classify acne scars and choose effective treatments for each type of scars. The method of applying fillers during scar treatment. Key words: Acne scar treatment, ice pick, box scar, rolling scar, subcision, filler

The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Background and Aim: Recent data draw attention to the effect of body composition, insulin resistance and adipocytokines to acne vulgaris (AV) development. The aim of this study to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. Material and Methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4) and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. Results: In AV patients, pretreatment HOMA-IR and adipocytokine level was not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values were found (p=0.028). Isotretinoin therapy maintained lower mean resistin levels (p = 0.016), higher mean RBP4 levels (p = 0.040), but not affected the mean adiponectin and leptin levels (p = 0.113, p = 0.125, respectively). Conclusions: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in insulin resistance is not dependent on age, BMI, BFM and lipid levels of these patients. Key words: Acne vulgaris, adipocytokine, insulin sensitivity

PROFIL AKNE VULGARIS DI RSUP Prof. Dr. R. D. KANDOU MANADO PERIODE 2009-2011

Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles that commonly occurs in adolescence and can heal itself. The purpose of this study was to determine the profile of acne vulgaris in Dermatovenereology of Prof. Dr. R. D. Kandou Manado in 2009-2011. This study was conducted retrospectively in patients with acne vulgaris who came to the Dermatology clinic in 2009-2011. The data were recorded from medical records of the amounts of patients, gender, age, occupation / education, lesion location, and the type of acne. The results showed that of a total of 10003 visits in 2009-2011 there of 121 patients (3.59%) were new cases of acne vulgaris, acne vulgaris in patients dominance of female patients by 75 patients (61.9%), the age group most at 15-24 years old is 76 patients (62.8%), the highest educational status on the student group is 73 patients (60.3%), the most lesions location are on the face, most types of acne is papulopustular. Key words: acne vulgaris, inflammation, pilosebaceous Abstrak: Akne vulgaris adalah penyakit peradangan menahun folikel pilosebasea yang umumnya terjadi pada masa remaja dan dapat sembuh sendiri. Tujuan dari penelitian ini untuk mengetahui profil akne vulgaris di poliklinik Kulit dan Kelamin RSUP Prof Dr R. D. Kandou Manado pada tahun 2009–2011. Penelitian ini dilakukan secara retrospektif pada pasien dengan akne vulgaris yang datang ke poliklinik Kulit dan Kelamin pada tahun 2009–2011. Dilakukan pencatatan data dari catatan medik mengenai jumlah pasien, jenis kelamin, usia, pekerjaan/pendidikan, lokasi lesi, dan jenis akne. Hasil yang diperoleh menunjukkan bahwadari total 10003 kunjungan pada tahun 2009–2011 terdapat 121pasien (3,59%) merupakan penderita baru akne vulgaris, pasien akne vulgaris di dominasi pasien perempuan sebanyak 75 pasien (61,9%), kelompok usia terbanyak pada usia 15 – 24 tahun yaitu 76 pasien (62,8%), status pendidikan terbanyak pada kelompok pelajar yaitu 73 pasien (60,3%), lokasi lesi terbanyak yaitu di bagian wajah, jenis akne terbanyak yaitu papulopustuler. Kata kunci: akne vulgaris, pilosebasea, radang