The Neutrophil-Lymphocyte Ratio and its Relationship with Insulin Resistance in Obesity

Background and aim: In this study, we aimed to investigate the neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes, and the relationship between N/L ratio and insulin resistance (IR) in obesity. Materials and Methods: Ninety six patients and 40 healthy controls were included in this study. Patients’ blood glucose levels, insulin levels, and hemogram parameters upon 8 hours of fasting were determined. Body mass index (BMI) and homeostasis model assessment insulin resistance (HOMA-IR) values were calculated. Results: Neutrophil numbers were found to be higher among IR obese patients than among non-IR obese patients. The N/L ratio was, moreover, found to be higher among IR obese patients, when compared to non IR obese. A positive correlation was found between insulin resistance and both neutrophil and WBC counts. Another positive correlation was also found between insulin levels and the N/L ratio, WBC, and neutrophil counts. Discussion: In our study, leukocyte numbers and subtypes were determined to be higher among obese individuals than among healthy individuals. The N/L ratio had increased significantly only among obese patients who have insulin resistance. Further studies are needed in order to better demonstrate the relationship between the N/L ratio and insulin resistance/inflammation. Key Words: Neutrophil-Lymphocyte Ratio, Obesity, Insulin Resistance

JUMLAH NEUTROFIL PADA PETANI TERPAPAR PESTISIDA DI KELURAHAN RURUKAN KECAMATAN TOMOHON TIMUR

Neutrophil is a part of white blood cells that known as phagocyte cells and serves as the immunological defense systems which protect the human organism from the invading foreign objects. Pesticides are poisonous substances used to eradicate pests. One of the effects of pesticides exposure on health is impaired on blood profile. This study aimed to determine the neutrophils count in farmers that exposed to pesticides at Rurukan village, East Tomohon District. This study was conducted using cross sectional study plan. The research subjects were 50 people who have met the inclusion criteria. The neutrophil counts were measured using ABX Pentra XL 80. In this study, the mean of neutrophil counts were 3,850 cells/mm3. It can be concluded most of the subjects had a neutrophil counts below the normal value. Key words: Neutrophil, pesticides Abstrak: Neutrofil adalah salah satu bagian dari sel darah putih yang merupakan sel spesialis fagositik dan berfungsi sebagai pertahanan pertama tubuh terhadap invasi suatu benda asing. Pestisida adalah suatu zat yang bersifat racun yang berfungsi untuk memberantas organisme pengganggu tanaman. Salah satu dampak dari paparan pestisida terhadap kesehatan yaitu gangguan pada profil darah. Penelitian ini bertujuan untuk mengetahui gambaran jumlah neutrofil pada petani terpapar pestisida di kelurahan Rurukan kecamatan Tomohon Timur. Penelitian ini dilakukan menggunakan rancangan potong lintang. Subyek penelitian berjumlah 50 responden. Jumlah neutrofil diukur menggunakan alat ABX Pentra XL 80. Hasil pada penelitian ini didapatkan rerata jumlah neutrofil subyek adalah 3.850 sel/mm3. Dapat disimpulkan bahwa sebagian besar subyek memiliki jumlah neutrofil di bawah nilai normal. Kata Kunci: Neutrofil, pestisida