black urine
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2020 ◽  
Vol 40 (9) ◽  
pp. 651-661
Author(s):  
Kamila P.F. Martins ◽  
Vitor H.T. Padilha ◽  
Tércio K. Damasceno ◽  
Marcos A. Souza ◽  
Emanoelly M.S. Silva ◽  
...  

ABSTRACT: Copper is an essential micromineral in animal feed; however, when consumed in excess, it can cause liver necrosis, hemolytic crisis, hemoglobinuric nephrosis and death in cattle. Although uncommon in this species, copper poisoning occurs as a result of exacerbated supplementation, deficiency of antagonist microminerals, or previous liver lesions. An outbreak of chronic copper poisoning is reported in semi-confined cattle after supplementation with 50 mg/Kg of dry matter copper. The cattle showed clinical signs characterized by anorexia, motor incoordination, loss of balance, jaundice, brownish or black urine, diarrhea and death, or were found dead, 10 to 302 days after consumption. Of the 35 cattle that died, 20 underwent necropsy, whose frequent findings were jaundice, enlarged liver with evident lobular pattern, black kidneys, and urinary bladder with brownish to blackish content. Microscopically, the liver showed vacuolar degeneration and/or zonal hepatocellular centrilobular or paracentral coagulative necrosis, in addition to cholestasis, mild periacinal fibrosis, apoptotic bodies, and mild to moderate mononuclear inflammation. Degeneration and necrosis of the tubular epithelium and intratubular hemoglobin cylinders were observed in the kidneys. Copper levels in the liver and kidneys ranged from 5,901.24 to 28,373.14 μmol/kg and from 303.72 to 14,021 μmol/kg, respectively. In conclusion, copper poisoning due to excessive nutritional supplementation is an important cause of jaundice, hemoglobinuria, and death in semi-confined cattle.


2020 ◽  
Vol 97 (6) ◽  
pp. 1303
Author(s):  
Sidharth Kumar Sethi ◽  
Rupesh Raina ◽  
Ronith Chakraborty ◽  
Vijay Kher
Keyword(s):  

2020 ◽  
Vol 133 (6) ◽  
pp. e304-e305
Author(s):  
Isabella Albanese ◽  
Lorne Schweitzer ◽  
Blair Carl Schwartz
Keyword(s):  

2020 ◽  
Vol 74 ◽  
pp. 104-105
Author(s):  
Alejandro Morales Ortega ◽  
Carmen Cristóbal Varela ◽  
Santiago Serrano Fiz
Keyword(s):  

2020 ◽  
Vol 13 ◽  
pp. 117954762098189
Author(s):  
Salwa A Koubaissi ◽  
Reem G Al Assaad ◽  
Ziad Itani ◽  
Imad Bouakl

Clostridium Perfringens is an anaerobic gram-positive bacillus able to produce different types of toxins and can cause septicemia. The mechanism is through translocation from a previously colonized gastrointestinal or genital tract. Massive intravascular hemolysis induced by this bacterium is a rare presentation reported in only 7% to 15% of cases of Clostridium Perfringens bacteremia with a mortality rate reaching 90%.We present the case of a middle-aged man with metastatic melanoma having black-colored urine as the first sign of massive hemolysis along with mild methemoglobinemia. Despite timely management, the patient progressed into septic shock with severe hypoxia and passed away. Postmortem, blood cultures grew clostridium perfringens. Black-colored urine and blood samples, sepsis-induced mild methemoglobinemia and acute massive hemolysis should raise concern for Clostridium Perfringens sepsis in the appropriate clinical settings.


2019 ◽  
Vol 96 (1136) ◽  
pp. 358-358
Author(s):  
Masaaki Hino ◽  
Akira Kuriyama ◽  
Yoshiaki Anzai
Keyword(s):  

2014 ◽  
Vol 47 (12) ◽  
pp. 1132-1135
Author(s):  
Nandkishor S. Chindarkar ◽  
Landen L. Rentmeester ◽  
Binh T. Ly ◽  
Robert L. Fitzgerald
Keyword(s):  

2013 ◽  
Vol 2013 (sep13 1) ◽  
pp. bcr2013200771-bcr2013200771 ◽  
Author(s):  
L. R. Liu ◽  
M.-Y. Huang ◽  
S.-T. Huang
Keyword(s):  

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