Two New Taxane Diterpenoids From Taxus baccata

Two new diterpenoids named 13-oxo-wollifoliane-10,15-olide (1) and 19-acetoxy-7,9,10-deacetyl-baccatin VI (2), along with 14 known taxanes (3-16), were isolated from Taxus baccata. The structures of these compounds were elucidated by 1-dimensional and 2-dimensional nuclear magnetic resonance spectra, high-resolution electrospray ionization-mass spectrometry, and infrared spectroscopy. Structurally, 13-oxo-wollifoliane-10,15-olide (1) is the first taxane diterpenoid possessing an unusual carbonyl group at the C-13 position of the 11(15→1),11(10→9)bis- abeo-taxane structure (5/6/6/6/4 skeleton), and 19-acetoxy-7,9,10-deacetyl-baccatin VI (2) is a new compound containing an acetoxy group at the C-19 position of 6/8/6/4-taxane. Among the 14 known taxane compounds 3-16, compounds 7 and 9 were first isolated and reported from T. baccata. Several compounds (3-16) were evaluated for cytotoxicity against MCF-7 and HCT116 human cancer cell lines, but none of them showed considerable cytotoxic activity.

A New Taxane Diterpenoid and a New Neolignan from Taxus baccata

Two new compounds, baccataxinine (1) and baccalignan (2), were isolated from the Taxus baccata, together with 16 known ones. Their structures were elucidated by comprehensive spectroscopic analyses of HR-ESI-MS, NMR and IR. Compound 1 is a taxane diterpenoid possessing a rare dioxolane ring between C-1 and C-2, while 2 is the first benzofuran neolignan from this species. Furthermore, they were also evaluated for their α-glucosidase inhibitory activity, but none of them showed considerable inhibitory effects.