The Complement System in Ovarian Cancer: An Underexplored Old Path

Ovarian cancer is one of the most lethal gynecological cancers. Current therapeutic strategies allow temporary control of the disease, but most patients develop resistance to treatment. Moreover, although successful in a range of solid tumors, immunotherapy has yielded only modest results in ovarian cancer. Emerging evidence underscores the relevance of the components of innate and adaptive immunity in ovarian cancer progression and response to treatment. Particularly, over the last decade, the complement system, a pillar of innate immunity, has emerged as a major regulator of the tumor microenvironment in cancer immunity. Tumor-associated complement activation may support chronic inflammation, promote an immunosuppressive microenvironment, induce angiogenesis, and activate cancer-related signaling pathways. Recent insights suggest an important role of complement effectors, such as C1q or anaphylatoxins C3a and C5a, and their receptors C3aR and C5aR1 in ovarian cancer progression. Nevertheless, the implication of these factors in different clinical contexts is still poorly understood. Detailed knowledge of the interplay between ovarian cancer cells and complement is required to develop new immunotherapy combinations and biomarkers. In this context, we discuss the possibility of targeting complement to overcome some of the hurdles encountered in the treatment of ovarian cancer.

Updating our understanding of situation awareness in relation to remote operators of autonomous vehicles

The introduction of autonomous vehicles (AVs) could prevent many accidents attributable to human driver error. However, even entirely driverless vehicles will sometimes require remote human intervention. Current taxonomies of automated driving do not acknowledge the possibility of remote control of AVs or the challenges that are unique to such a driver in charge of a vehicle that they are not physically occupying. Yet there are significant differences between situation awareness (SA) in normal driving contexts and SA in these remote driving operations. We argue that the established understanding of automated driving requires updating to include the context of remote operation that is likely to come in to play at higher levels of automation. It is imperative to integrate the role of the remote operator within industry standard taxonomies, so that regulatory frameworks can be established with regards to the training required for remote operation, the necessary equipment and technology, and a comprehensive inventory of the use cases under which we could expect remote operation to be carried out. We emphasise the importance of designing control interfaces in a way that will maximise remote operator (RO) SA and we identify some principles for designing systems aimed at increasing an RO’s sense of embodiment in the AV that requires temporary control.

INDIVIDUAL PREVENTIVE MEASURES TO PREVENT HOOLIGANISM

The article examines individual preventive measures to prevent hooliganism. Under the individual prevention of hooliganism, it was proposed to understand a complex of criminal and psychological measures and means aimed at the timely identification, prevention and correction of a person's personal qualities (value orientations, motives, etc.), which distort in her mind, prohibitions on violation of public order and morality are established and cause the desire to do hooligan actions with the aim of self-realization and demonstration of antisocial behavior. Most of the individual-prophylactic means of preventing hooliganism is to establish and correct personality traits that push it to demonstrate its aggression and insolence. The following stages of preventing hooliganism at the individual level are proposed: 1) identification of persons inclined to commit hooliganism (having certain dependencies, were brought to administrative / criminal liability for hooliganism, etc.); 2) establishing the features of the mechanism of criminal-illegal behavior (determination complex); 3) study of the personality of a criminal offender, his civic position and role in society (microsocial ties); 4) planning of measures taking into account the individual determination complex of the offender; 5) implementation of individual prophylactic means; 6) fixation of the achieved results and temporary control in order to timely prevent relapse. It is noted that the problem of preventing hooliganism is that it is often difficult to predict such actions, since sometimes even the offender himself cannot be responsible for his reactions to objective pathogens. It is believed that negative personality traits (their list are not exhaustive), both individually and in combination with others can form an unlawful aspiration of a person to commit a criminal offense. That is why the importance of timely identification of persons potentially capable of antisocial behavior is emphasized.

Pre-During-Post Lockdown Air Quality in Adyar, Chennai, India Amid COVID-19 Pandemic

The COVID-19 pandemic has shoved most of the countries to implement restrictions for transportation and all other social activities to minimize spread of disease to the people. India is the second most populated country in the world which has implemented a historical complete lockdown throughout the country from the last week of March to April 2020 with an extension up to the first week of May 2020. This lockdown has slowed down the pollution levels in most of the cities in India within the first few weeks of the lockdown. In this view, the present study discusses the air quality scenario of Chennai, one of the megacities of India, scientifically. With the aid of air quality data of the Tamil Nadu Pollution Control Board, India, for five parameters such as PM 2.5 and P.M 10, sulphur dioxide, nitrogen dioxide and air quality index, the authors correlated the pre-during-post lockdown air quality of Adyar, Chennai. The results indicated that the concentrations of particulate matter reduced to about 50 � 80 % during the lockdown compared to pre-lockdown. The concentrations of sulphur dioxide and nitrogen dioxide were decreased to 50% and 20%, respectively, within the first week of lockdown. Further the data were compared with the pollution data for the past two years (2018 and 2019). The present study gives insight on the reduction of pollution in proportion to the temporary control of pollution source at particular interval could rejuvenate the environment.

Successful emergency management of a bleeding tracheoinnominate fistula

In this case, we describe a novel approach to achieving temporary haemostasis in acute massive haemorrhage from a bleeding tracheoinnominate fistula. We report the case of a 42-year-old man admitted to hospital after suffering 80% body surface area burns. Thirty days following the percutaneous insertion of a tracheostomy, spontaneous massive haemorrhage occurred via the tracheostomy stoma, the tracheostomy tube and the mouth. After hyperinflation of the tracheostomy cuff which controlled airway contamination, effective tamponade was achieved using a hyperinflated balloon on a Foley catheter that was introduced by direct laryngoscopy into the upper larynx above the tracheotomy stoma. This provided temporary control of the bleeding until definitive management through ligation of the innominate artery via median sternotomy.

Feasibility of a Portable Abdominal Insufflation Device for Controlling Intraperitoneal Bleeding After Abdominal Blunt Trauma

Uncontrolled bleeding contributes to 30% to 40% of trauma-related deaths and is the leading cause of potentially preventable deaths. Currently, there is no effective method available to first responders for temporary control of noncompressible intraabdominal bleeding while patients are transported to the hospital. Our previous studies demonstrated that abdominal insufflation provides effective temporary bleeding control. The study aims to prove the feasibility (insufflation to a target pressure) and safety (cardiovascular and respiratory effects) of a novel portable abdominal insufflation device (PAID) designed to control the intraperitoneal bleeding caused by abdominal trauma. The PAID prototype is based on a patented design and manufactured via additive manufacturing. PAID contains a 16-g CO2 cartridge and an electronic pressure transducer. PAID was tested on a bench top and a swine animal model. For the animal model study, the intraperitoneal pressure as well as cardiorespiratory parameters (hearth rate, SpO2 [peripheral capillary oxygen saturation], and blood pressure) were continuously monitored during the insufflation procedure. The prototype functioned according to specifications on both bench top and animal models. CO2 insufflation of the peritoneal cavity was delivered up the target 20 mm Hg and maintained for 30 minutes from 1 or 2 cartridges in the swine model. No intraoperative incidents were registered, and all the recorded physiological parameters were within normal limits. The PAID prototype is a feasible, easy to use device that provides quick, controlled, and safe insufflation of the peritoneal cavity. Future studies will focus on testing the next-generation, semiautomatic PAID prototype in a severe intraabdominal injury model.

Contemporary Utilization of Zone III REBOA for Temporary Control of Pelvic and Lower Junctional Hemorrhage Reliably Achieves Hemodynamic Stability in Severely Injured Patients

Background: Aortic occlusion is a valuable adjunct for management of traumatic pelvic and lower extremity junctional hemorrhage. Methods: The American Association for the Surgery of Trauma's Aortic Occlusion in Resuscitation for Trauma and Acute Care Surgery registry was reviewed for patients requiring Zone III resuscitative endovascular balloon occlusion of the aorta (REBOA) from eight verified trauma centers. After excluding patients in arrest, demographics, elements of treatment and outcomes were identified. Results: From Nov 2013 – Dec 2016, 30 patients had Zone III REBOA placed. Median age was 41.0 (IQR 38); median ISS 41.0 (IQR 12). Hypotension (SBP < 90mm Hg) was present on admission in 30.0% and tachycardia (HR > 100 bpm) in 66.7%. Before REBOA placement, vital signs changed in this cohort with hypotension in 83.3% and tachycardia noted in 90%. Median initial pH was 7.14 (IQR 0.22), and median admission lactate 9.9 mg/dL (IQR 5). Pelvic binders were utilized in 40%. Occlusion balloon devices included Coda™ (70%), ER-REBOA™ (13.3%), Reliant™ (10%). After REBOA, hemodynamics improved in 96.7% and stability (BP consistently > 90 mm Hg) was achieved in 86.7%. Median duration of REBOA was 53.0 mins (IQR 112). Median PRBC and FFP requirements were 19.0 units (IQR (17) and 17.0 units (IQR 14), respectively. One amputation unrelated to REBOA utilization was required. Systemic complications included AKI (23.3%) and MODS (10%). REBOA specific complications included groin hematoma (3.3%) and distal thromboembolization (16.7%). Survival to discharge was 56.7%, with in-hospital deaths occurring in the ED 7.7%, OR 23.1%, ICU 69.2%. Conclusions: This review discusses the specifics of the contemporary use of Zone III REBOA placement as well as local and systemic complications for patients in extremis with pelvic/junctional hemorrhage. Further review is required determine optimal patient selection. Level of Evidence: Level IV Study Type: Therapeutic Key Words Zone III REBOA, Pelvic Bleeding, Junctional Hemorrhage

A Cluster Sleep-Wake Scheduling Algorithm Based on 3D Topology Control in Underwater Sensor Networks

3D topology control in underwater sensor networks is of great significance to ensuring reliable and efficient operation of the network. In this paper, by analyzing the characteristics of an underwater sensor network, we take the cube as the basic unit to perform 3D partition of the monitoring area, define the 3D partition unit and basic cluster structure of the underwater sensor network, and arrange rotating temporary control nodes in the cluster. Then, a cluster sleep-wake scheduling algorithm is proposed that compares the remaining node energy. It selects the node with the largest remaining energy as the working node, and the remaining nodes complete the transition of dormancy and waiting states as long as they reach the preset dormancy time. The node state settings of this phase are completed by the temporary control node. Temporary control nodes selecting and sleep-wake scheduling are used in the algorithm through 3D topology control, which reduces energy consumption and guarantees maximum sensing coverage of the entire network and the connection rate of active nodes. Simulation results further verify the effectiveness of the proposed algorithm.

MEANS OF SUGGESTIBILITY AND THEIR EVOLUTION STAGES IN ARABIC SOCIO-POLITICAL ARTICLES

With the dawn of printed press on the shores of the Arabic speaking world, the methods of impacting an individual’s cognition have been changed for the first time in many centuries. The rise of political and socio-political press in the region overall and in Egypt in particular was likely a by-product of Western intervention in the region, more specifically, Napoleon Bonaparte’s campaign resulting in his temporary control of Egypt. It too was Napoleon who created the first publishing houses in Egypt and it was his political views that were being spread through them. Expanding in detail on multiple sources to delve into the relevant periods, we have worked through numerous newspapers and publishers of socio-political articles in the Middle East and have noticed that Egyptian newspapers have managed to be representative of the Arab speaking printed press in the region. Egyptian editori- als have showcased the forefront of suggestive means with the purpose of leaving an imprint on the reader’s cognition, despite the fact that Egypt was not the first nation with a printed press capable of printing in Arabic. In this study we utilise quotes and examples from a range of socio-political press articles, dated as far back as 1967, as we provide examples backing our hypotheses for the changes in suggestive tactics used by the authors and editorials in their relevant periods. However, our goal in this article was not to focus on the suggestive means themselves in depth, but to rather provide evi- dence pointing to the fact that these suggestive methods have in fact undergone a process of evolution in their own right, changing with time and thus becoming more advanced and author-specific in the process. The possibility to spread a specific subjective position of an author in society without a need for speeches and the accompanying crowds became one of the defining factors to impact and shape the Arab speaking society since the XIX century. The efficacy of suggestive means in printed media has remained in present days with further evolution imminent due to the digitalisation of information, thus making suggestibility a more important aspect of printed press to explore than ever before.

FUNCTIONS OF PATENTS

So far, we've seen that patents grant inventors ownership of their original ideas, giving them temporary control over who can use those ideas. This system shows up in some form or another in most all developed nations, because it is so important to a country's development. Patents affect society in a number of a ways, but at their core, they serve a very basic function: They help encourage the advancement of science and technology.Keyword : Functions Of Patents