Treating Patients with Atypical Familial Hemolytic Uremic Syndrome (aHUS) In the Critical Care Setting: A Case and Discussion

Hemolytic Uremic Syndrome (HUS) is usually recognized as the diarrheal associated (D+) and less as atypical/non diarrheal (aHUS). AHUSis caused by over activation of the alternative pathway of the complement system. It is a rare genetic disorder that is not often seen. Here we present a case of a patient with aHUS, who came to our ICU, discuss the pathophysiology, and how to treat and monitor a patient with aHUS with plasmapheresis and eculizumab in the critical care setting