s100b secretion
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2021 ◽  
Vol 22 (11) ◽  
pp. 5526
Author(s):  
Adriana Kubis-Kubiak ◽  
Benita Wiatrak ◽  
Agnieszka Piwowar

Alzheimer’s disease (AD) is attracting considerable interest due to its increasing number of cases as a consequence of the aging of the global population. The mainstream concept of AD neuropathology based on pathological changes of amyloid β metabolism and the formation of neurofibrillary tangles is under criticism due to the failure of Aβ-targeting drug trials. Recent findings have shown that AD is a highly complex disease involving a broad range of clinical manifestations as well as cellular and biochemical disturbances. The past decade has seen a renewed importance of metabolic disturbances in disease-relevant early pathology with challenging areas in establishing the role of local micro-fluctuations in glucose concentrations and the impact of insulin on neuronal function. The role of the S100 protein family in this interplay remains unclear and is the aim of this research. Intracellularly the S100B protein has a protective effect on neurons against the toxic effects of glutamate and stimulates neurites outgrowth and neuronal survival. At high concentrations, it can induce apoptosis. The aim of our study was to extend current knowledge of the possible impact of hyper-glycemia and -insulinemia directly on neuronal S100B secretion and comparison to oxidative stress markers such as ROS, NO and DBSs levels. In this paper, we have shown that S100B secretion decreases in neurons cultured in a high-glucose or high-insulin medium, while levels in cell lysates are increased with statistical significance. Our findings demonstrate the strong toxic impact of energetic disturbances on neuronal metabolism and the potential neuroprotective role of S100B protein.


2021 ◽  
pp. 135776
Author(s):  
Adriana Fernanda K. Vizuete ◽  
Juliana de Lima Cordeiro ◽  
Juliana Dalibor Neves ◽  
Marina Seady ◽  
Lucas Kich Grun ◽  
...  

2018 ◽  
Vol 44 (2) ◽  
pp. 301-311 ◽  
Author(s):  
Adriana Fernanda K. Vizuete ◽  
Fernanda Hansen ◽  
Carollina Da Ré ◽  
Miriara B. Leal ◽  
Fabiana Galland ◽  
...  

2016 ◽  
Vol 121 ◽  
pp. 758-772 ◽  
Author(s):  
Marco Antonio Ceschi ◽  
Jessie Sobieski da Costa ◽  
João Paulo Bizarro Lopes ◽  
Viktor Saraiva Câmara ◽  
Leandra Franciscato Campo ◽  
...  

2016 ◽  
Vol 41 (6) ◽  
pp. 1420-1429 ◽  
Author(s):  
Krista Minéia Wartchow ◽  
Ana Carolina Tramontina ◽  
Daniela F. de Souza ◽  
Regina Biasibetti ◽  
Larissa D. Bobermin ◽  
...  

Amino Acids ◽  
2015 ◽  
Vol 48 (2) ◽  
pp. 375-385 ◽  
Author(s):  
Fernanda Hansen ◽  
Cíntia Eickhoff Battú ◽  
Márcio Ferreira Dutra ◽  
Fabiana Galland ◽  
Franciane Lirio ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Cristiane Batassini ◽  
Núbia Broetto ◽  
Lucas Silva Tortorelli ◽  
Milene Borsoi ◽  
Caroline Zanotto ◽  
...  

Both glial fibrillary acidic protein (GFAP) and S100B have been used as markers of astroglial plasticity, particularly in brain injury; however, they do not necessarily change in the same time frame or direction. Herein, we induced a Parkinson’s disease (PD) model via a 6-OHDA intrastriatal injection in rats and investigated the changes in GFAP and S100B using ELISA in the substantia nigra (SN), striatum, and cerebrospinal fluid on the 1st, 7th, and 21st days following the injection. The model was validated using measurements of rotational behaviour induced by methylphenidate and tyrosine hydroxylase in the dopaminergic pathway. To our knowledge, this is the first measurement of cerebrospinal fluid S100B and GFAP in the 6-OHDA model of PD. Gliosis (based on a GFAP increase) was identified in the striatum, but not in the SN. We identified a transitory increment of cerebrospinal fluid S100B and GFAP on the 1st and 7th days, respectively. This initial change in cerebrospinal fluid S100B was apparently related to the mechanical lesion. However, the 6-OHDA-induced S100B secretion was confirmed in astrocyte cultures. Current data reinforce the idea that glial changes precede neuronal damage in PD; however, these findings also indicate that caution is necessary regarding the interpretation of data in this PD model.


Author(s):  
Daniela Fraga de Souza ◽  
Krista Wartchow ◽  
Fernanda Hansen ◽  
Paula Lunardi ◽  
Maria Cristina Guerra ◽  
...  

Life Sciences ◽  
2013 ◽  
Vol 92 (12) ◽  
pp. 701-707 ◽  
Author(s):  
Paula Lunardi ◽  
Patrícia Nardin ◽  
Maria Cristina Guerra ◽  
Renata Abib ◽  
Marina Concli Leite ◽  
...  
Keyword(s):  

2013 ◽  
Vol 1491 ◽  
pp. 14-22 ◽  
Author(s):  
Caroline Zanotto ◽  
Renata Torres Abib ◽  
Cristiane Batassini ◽  
Lucas Silva Tortorelli ◽  
Regina Biasibetti ◽  
...  

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