<p>Background. The risk of chronic kidney failure increases by 3–10 times with the steady increasing of uric<br />acid level in the blood. It is known that the protein fractions is closely correlated with the level of uric acid.<br />Objective. Microalbuminuria and microglobulinuria are predictors of kidney damage. The study involved<br />50 patients with gout who had never received preventive treatment of gouty nephropathy. We choosed Canephron<br />N (Bionorica, Neumarkt, Germany) as a combined phytodrug with nephroprotective effect. All studied patients<br />were men with obesity.<br />Results. According to standard examination kidney damage haven’t been found, but laboratory tests on<br />microproteinuria showed that the vast majority of patients have signs of subclinical gouty nephropathy.<br />Conclusions. Canephron N in complex gout treatment helps to decrease uric acid level in the blood and<br />increase its excretion.<br />KEY WORDS: gout, chronic kidney disease, hyperuricemia, canephron n</p>