Η επίδραση της θειαμαζόλης στη θυρεοειδική και ωοθηκική δραστηριότητα σε προβατίνες Καραγκούνικης φυλής

The objectives of the present study were to investigate the feasibility to extent the breeding season after pharmacological thyroid gland suppression in Karagouniko ewes. During the first experimental phase, we studied the circannual variation in thyroxin and triiodiothyronin concentration in 10 ewes. During the next year, on the basis of the results obtained from the first phase, thiamazole was administered in 10 of 20 ewes. Sample analysis from the first experiment showed that T3 and T4 fluctuate throughout the year, but at the period of increasing daylight their concentrations were higher in comparison to those of the periods of decreasing daylight. A clear and abrupt increase in both T3 and T4 was observed during the end of spring. In the second experiment we attempted to eliminate this increase by thiamazole administration. Thiamazole suppressed T3 and T4 increase, but estrous cycle characteristics (ovarian structures, progesterone concentration) and mainly the duration of the breeding season did not differ between the two groups. We infer that stronger and possibly longer thyroid gland suppression is required in order an extension of the breeding season to be achieved.

TO THE QUESTION OF DIAGNOSTIC CRITERIA PERFECTION IN VIEW CIRCANNUAL VARIATION OF ORGANISM FUNCTIONING ADAPTIVE SYSTEMS IN CONDITIONS OF WESTERN SIBERIA

Purpose of the research was studying circannual variation of parameters of hormonal regulation, lipids, oxidative systems of an organism of healthy men and women in conditions of Western Siberia.Monthly, within five years (2005–2009) on conditions of the voluntary informed consent 580 healthy donors (370 men and 210 women) in the age of from 25 up to 47 have been surveyed. In blood serum defined concentration of cortisol, insulin, thyroid hormones, concentration of cholesterol and other lipids, markers of stress and oxidative. Obtained data have been processed by adequate methods of the mathematical and statistical analysis.The analysis of results has shown that activity of functioning systems adaptation an of organism at all levels of the organization undergoes essential changes within a year. Revealed correlations are the certificate of cause and effect attitudes between the systems, providing adaptive mechanisms in constantly changing conditions of a living environment. The received results testify to an absolute must of revision of diagnostic criteria and expansions of concept of norm in view of circannual variation of functioning of physiological systems of an organism.