CLINICAL AND NEUROIMAGING CORRELATES OF LEIGH SYNDROME , A CASE SERIES AND REVIEW OF LITERATURE

Leigh syndrome, also referred to as Sub acute necrotising encephalopathy usually presents with symptoms like developmental delay, regression of neurological skills and sudden death. Approximately 25% of the patients are abnormal at birth with features like hypotonia, lactic acidosis, feeding problems, hypoglycemia, hyperbilirubinemia, cardiac complications, seizures and/or hyperammonemia. Here, we present 6 cases of Leigh's disease , who presented within 6 months of life with neurological regression and hypotonia as the predominent manifestations with MRI ndings showing Bilateral symmetrical hyperintensities in T2 weighted images which are characteristic ndings in Leigh's disease.

Treatment of Acute Necrotising Pancreatitis and Its Complications: The Surgeon’s Perspective

Acute necrotising pancreatitis (ANP) is associated with high complication and mortality rates. It is still difficult for the surgeon to choose and schedule the most appropriate treatment. Compared to the past, the current minimally invasive “step-up” approach enables better outcomes in terms of morbidity/mortality, notwithstanding long periods of hospitalisation, and above all ensures better levels of residual pancreatic function. We hereby report the case of a patient hospitalised in our division for approximately 4 months with a diagnosis of ANP complicated by infection and late bleeding, handled with a sequential approach.

Acute Complicated Necrotising Pancreatitis Treated with Video-Assisted Retroperitoneal Debridement

Acute necrotising pancreatitis is a complex disease with high morbidity and mortality rates. In cases of infected necrosis, treatment consists of a step-up approach involving endoscopic or mini-invasive surgical methods. In some cases, there are extremely rare complications. In addition, the underlying comorbidities worsen the course of the disease. We report a case of a 32-year-old male with acute necrotising pancreatitis complicated with recurrent retroperitoneal abscesses, sepsis, iatrogenic pylephlebitis, exacerbation of underlying Crohn’s disease, and the outcome of the treatment was successful. During the period of hospitalisation, one ultrasound-guided percutaneous drainage, two computed tomography-guided punctures of the retroperito-neal space (percutaneous and transhepatic) and five video-assisted retroperitoneal debridement procedures were carried out. The patient was discharged after 185 days of hospitalisation.