Drug resistance: from bacteria to cancer

The phenomenon of drug resistance has been a hindrance to therapeutic medicine since the late 1940s. There is a plethora of factors and mechanisms contributing to progression of drug resistance. From prokaryotes to complex cancers, drug resistance is a prevailing issue in clinical medicine. Although there are numerous factors causing and influencing the phenomenon of drug resistance, cellular transporters contribute to a noticeable majority. Efflux transporters form a huge family of proteins and are found in a vast number of species spanning from prokaryotes to complex organisms such as humans. During the last couple of decades, various approaches in analyses of biochemistry and pharmacology of transporters have led us to understand much more about drug resistance. In this review, we have discussed the structure, function, potential causes, and mechanisms of multidrug resistance in bacteria as well as cancers.

Atomic mapping of periodic dipole waves in ferroelectric oxide

A dipole wave is composed of head-to-tail connected electric dipoles in the form of sine function. Potential applications in information carrying, transporting, and processing are expected, and logic circuits based on nonlinear wave interaction are promising for dipole waves. Although similar spin waves are well known in ferromagnetic materials for their roles in some physical essence, electric dipole wave behavior and even its existence in ferroelectric materials are still elusive. Here, we observe the atomic morphology of large-scale dipole waves in PbTiO3/SrTiO3 superlattice mediated by tensile epitaxial strains on scandate substrates. The dipole waves can be expressed in the formula of y = Asin (2πx/L) + y0, where the wave amplitude (A) and wavelength (L) correspond to 1.5 and 6.6 nm, respectively. This study suggests that by engineering strain at the nanoscale, it should be possible to fabricate unknown polar textures, which could facilitate the development of nanoscale ferroelectric devices.

Spectra of elliptic potentials and supersymmetric gauge theories

We study a relation between asymptotic spectra of the quantum mechanics problem with a four components elliptic function potential, the Darboux-Treibich-Verdier (DTV) potential, and the Omega background deformed N=2 supersymmetric SU(2) QCD models with four massive flavors in the Nekrasov-Shatashvili limit. The weak coupling spectral solution of the DTV potential is related to the instanton partition function of supersymmetric QCD with surface operator. There are two strong coupling spectral solutions of the DTV potential, they are related to the strong coupling expansions of gauge theory prepotential at the magnetic and dyonic points in the moduli space. A set of duality transformations relate the two strong coupling expansions for spectral solution, and for gauge theory prepotential.