Significance of Splenectomy for Upper Gastric Carcinoma With Invasion to the Greater Curvature

This study aimed to clarify the significance of splenectomy (Sp) for upper gastric carcinoma with invasion to the greater curvature. The Japan Clinical Oncology Group (JCOG) conducted a phase III randomized clinical trial (JCOG 0110), where the significance of Sp in total gastrectomy (TG) for upper gastric carcinoma without invasion to the greater curvature was not proved because Sp did not contribute to an improved prognosis. From 1992 to 2010, 167 patients underwent TG for carcinoma of the upper stomach, except for patients with carcinoma of the residual stomach. Among them, 60 patients with tumor invasion to the greater curvature of the upper stomach (Gre group) were enrolled. Within the Gre group, the following factors were compared between the Sp group (n = 30) and non-Sp group (n = 30): patient background, postoperative staging, rate of neoadjuvant chemotherapy, surgical outcomes and rates of R0 resection, morbidity, adjuvant chemotherapy, and overall survival (OS). The Gre group patients were relatively younger, and tumor size and the numbers of Borrmann type 4 tumors, circumferential lesions, undifferentiated type lesions, and advanced cases were significantly larger than those in the non-Gre group. There were also significant differences in patient age and organs resected other than the spleen between the Sp group and non-Sp group. There was no significant difference in OS between the 2 groups. The significance of Sp for upper gastric carcinoma with invasion to the greater curvature was equivocal because the patients received no survival benefit by undergoing Sp.

Simplified technique for reconstruction of the digestive tract after total and subtotal gastrectomy for gastric cancer

BACKGROUND: Laparoscopic surgery has been increasingly applied to gastric cancer surgery. Gastrointestinal tract reconstruction totally done by laparoscopy also has been a challenge for those who developed this procedure. AIM - To describe simplified reconstruction after total or subtotal gastrectomy for gastric cancer by laparoscopy and the results of its application in a series of cases. METHODS - In the last four years, 75 patients were operated with gastric cancer and two with GIST. Thirty-four were women and 43 men. The age ranged from 38 to 77 years with an average of 55 years. In two patients with GIST a total and a subtotal gastrectomy were performed. In the other 75 patients were done 21 total gastrectomies and 54 subtotal. In all cancers, gastrectomy with D2 lymphadenectomy was completed with at least 37 lymph nodes removed. Was used in these operations a modified laparoscopic technique proposed by the authors consisting in a latero lateral esophagojejunal anastomosis with linear stapler in TG as well in STG, and reconstruction of the digestive continuity also in the upper abdomen. RESULTS - The intraoperative and immediate postoperative course were uneventful, except for one case of bleeding due to an opening clip, necessitating re-intervention. The operative time was 300 minutes, with no difference between total or subtotal gastrectomy. The number of lymph nodes removed varied from 28 to 69, averaging 37. Postoperative staging showed one case in T4 N2 M0; 13 in T2 N0 MO; 27 in T2 N1 M0; 24 in T3 N1 M0 and 10 in T3 N2 M0. Complication in only one case was observed on the 10th postoperative day with a small anastomotic leakage in esophagojejunal anastomose with spontaneous closure. CONCLUSION - The patient's evolution with no complications, no mortality and just one small anastomotic leakage with no systemic repercussions is a strong indication of the liability and feasibility of this innovative technical method.