plasma endotoxin level
Recently Published Documents


TOTAL DOCUMENTS

15
(FIVE YEARS 1)

H-INDEX

3
(FIVE YEARS 0)

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2788
Author(s):  
Qian Xiao ◽  
Yi-Hsiu Chen ◽  
Satwika Arya Pratama ◽  
Ya-Ling Chen ◽  
Hitoshi Shirakawa ◽  
...  

The purpose of this research was to investigate the prophylactic effects of glutamine on muscle protein synthesis and degradation in rats with ethanol-induced liver injury. For the first 2 weeks, Wistar rats were divided into two groups and fed a control (n = 16) or glutamine-containing diet (n = 24). For the following 6 weeks, rats fed the control diet were further divided into two groups (n = 8 per group) according to whether their diet contained no ethanol (CC) or did contain ethanol (CE). Rats fed the glutamine-containing diet were also further divided into three groups (n = 8 per group), including a GG group (glutamine-containing diet without ethanol), GE group (control diet with ethanol), and GEG group (glutamine-containing diet with ethanol). After 6 weeks, results showed that hepatic fatty change, inflammation, altered liver function, and hyperammonemia had occurred in the CE group, but these were attenuated in the GE and GEG groups. Elevated intestinal permeability and a higher plasma endotoxin level were observed in the CE group, but both were lower in the GE and GEG groups. The level of a protein synthesis marker (p70S6K) was reduced in the CE group but was higher in both the GE and GEG groups. In conclusion, glutamine supplementation might elevate muscle protein synthesis by improving intestinal health and ameliorating liver damage in rats with chronic ethanol intake.


Author(s):  
Tomoharu Shimizu ◽  
Toru Obata ◽  
Hiromichi Sonoda ◽  
Hiroya Akabori ◽  
Tohru Miyake ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document