Prescription rules of Qingzhu Fu, Ziming Chen, and Qian Wu for threatened miscarriage based on traditional Chinese medicine inheritance auxiliary platform

Background: To explore the prescription rules of famous ancient physicians in the treatment of threatened miscarriage. Methods: Traditional Chinese Medicine (TCM) prescriptions for threatened miscarriage were screened out of Fu Ren Da Quan Liang Fang by Ziming Chen, Yi Zong Jin Jian by Qian Wu, and Fu Qing Zhu Nv Ke by Qingzhu Fu. Data were standardized and analyzed through the TCM inheritance auxiliary platform. Results: A total of 29 prescriptions for threatened miscarriage were screened. Dang Gui, E Jiao, Gan Cao, Chuan Xiong, Bai Shao were the top five frequently prescribed Chinese herbs. The common herb–herb combinations used by Ziming Chen contained E Jiao, Dang Gui, Chuan Xiong, Ai Ye, Cong Bai, and Sang Ji Sheng. Ren Shen, Gan Cao, and Bai Zhu were the common herbal groups used by Qingzhu Fu. Huang Qi, Shu Di Huang, Bai Shao, Dang Gui, and Gan Cao were one of Qian Wu’s core prescriptions, with Dang Gui and Chuan Xiong being the others. According to the analysis of four Qi, five flavors, and meridian tropism of the prescriptions, herbs with the warm nature, or with the sweet, pungent, bitter flavors topped the list of application. The top six meridian tropisms of high-frequency herbs were: liver, spleen, lung, kidney, heart, and stomach meridian. Conclusion: Based on the principle of restoring the balance within the organs and enriching Qi and blood, clinical treatment of threatened miscarriage involves invigorating the Chong and Ren channels, nourishing Yin, dispelling cold and wind, generating and activating blood, regulating and harmonizing Qi.

Maximum turnaround radius in f(R) gravity

The accelerating behavior of cosmic fluid opposes gravitational attraction at present epoch, whereas standard gravity is dominant at small scales. As a consequence, there exists a point where the effects are counterbalanced, dubbed turnaround radius, [Formula: see text]. By construction, it provides a bound on maximum structure sizes of the observed universe. Once an upper bound on [Formula: see text] is provided, i.e. [Formula: see text], one can check whether cosmological models guarantee structure formation. Here, we focus on [Formula: see text] gravity, without imposing a priori the form of [Formula: see text]. We thus provide an analytic expression for the turnaround radius in the framework of [Formula: see text] models. To figure this out, we compute the turnaround radius in two distinct cases: (1) under the hypothesis of static and spherically symmetric spacetime, and (2) by using the cosmological perturbation theory. We thus find a criterion to enable large scale structures to be stable in [Formula: see text] models, circumscribing the class of [Formula: see text] theories as suitable alternative to dark energy. In particular, we get that for constant curvature, the viability condition becomes [Formula: see text], with [Formula: see text] and [Formula: see text], respectively, the observed cosmological constant and the Ricci curvature. This prescription rules out models which do not pass the aforementioned [Formula: see text] limit.

Nieprzedawnialne roszczenia majątkowe w prawie cywilnym

The text deals with the question of proprietary claims in the Polish civil law, which are exempted from prescription. The existence of such claims is a clear exception from the general rule set forth in Article 117 of the Civil Code (hereinafter: “CC”), which embraces all the proprietary claims with the general concept of prescription after the elapse of particular term (specified further in the following provisions). The article tries to explore the premises behind the general concept of lack of prescription, as well as to identify particular reasons for disapplication of Article 117 CC on the grounds of particular types of claims. The statute exempts explicitly two types of claims from prescription. It is the case of Article 223 § 1 CC, declaring lack of prescription for the damage claims supplementary to vindicatory claim. Similarly, according to Article 220 CC prescription does not embrace a claim for dissolution of co-ownership. In the other instances, the similar conclusion is derived in interpretation, mainly upon functional and systematic arguments. The case-law and the private law scholarship identify five examples of such claims. In all of these instances, the main reason behind disapplication of prescription rules is the close link of this claims with real property. Prescription of these claims and, hence, the possibility to transform them into natural obligations, seem from this perspective counter-functional and difficult to reconcile with the other principles and provisions of property law. It pertains, first of all, to the claims for establishing a way of necessity ease (Article 145 and 146 CC). Secondly, the same view is adopted for art. 151 CC, regarding another type of easement – available in the case of unintentional introducing a building or another facility behind the border of the somebody else’s ground. Thirdly, in the similar case of the intruding with a construction into another real property, the lack of prescription is adopted as regards the claim for transfer of title to the occupied part of the ground (Article 231 § 1 CC). Fourthly, the lack of prescription has been approved for the claim for establishing a transmission servitude (art. 3052 CC). Fifthly, the same solution has been proposed for the claim for transfer of title in performance of the contract with solely obligatory effects. This interpretation has been, however, rejected in the subsequent case-law and does not seem to be acclaimed currently.

General safety profile of zolpidem: safety in elderly, overdose and rebound effects

SummaryThe different aspects of general safety of zolpidem are reviewed after analysing the safety data obtained in adults as well as in elderly patients. The low incidence of reported adverse events during the first three years of utilisation of zolpidem have corroborated the results of the clinical studies. The most frequent adverse effects are central nervous system (CNS) related but they can be largely prevented by respecting the recommended doses and prescription rules. In cases of acute overdoses, no severe complications have been attributed to zolpidem taken alone. In most of the studies carried out within the recommended treatment duration, abrupt treatment discontinuation was not associated with clinically significant rebound insomnia, and the available pre-clinical and clinical data indicate that the risk of abuse or dependence is minimal when prescribed according to the recommended doses of 10 mg in adults and 5 mg in elderly. Thus, with now well-established arguments on a large patient basis going in the same direction, the safety of zolpidem can authorise and justify its wide prescription in the short-term treatment of insomnia.