Capillarity and active cell movement at mesendoderm translocation in the Xenopus gastrula

During Xenopus gastrulation, leading edge mesendoderm (LEM) advances animally as wedge-shaped cell mass over the vegetally moving blastocoel roof (BCR). We show that close contact across the BCR-LEM interface correlates with attenuated net advance of the LEM, which is therefore pulled forward by tip cells while the remaining LEM frequently separates from the BCR. Nevertheless, lamellipodia persist on the detached LEM surface. They attach to adjacent LEM cells and depend on PDGF-A, cell surface fibronectin and cadherin. We argue that active cell motility on the LEM surface prevents adverse capillary effects in the liquid LEM tissue as it moves by being pulled. It counters tissue surface tension effects with oriented cell movement and bulges the LEM surface out to keep it close to the curved BCR without attaching to it. Proximity to the BCR is necessary in turn for the maintenance and orientation of lamellipodia that permit mass cell movement with minimal substratum contact. Together with a similar process in epithelial invagination, vertical telescoping, the cell movement at the LEM surface defines a novel type of cell rearrangement, vertical shearing.

Wind–MRI interactions in local models of protoplanetary discs – I. Ohmic resistivity

ABSTRACT A magnetic disc wind is an important mechanism that may be responsible for driving accretion and structure formation in protoplanetary discs. Recent numerical simulations have shown that these winds can take either the traditional ‘hourglass’ symmetry about the mid-plane, or a ‘slanted’ symmetry dominated by a mid-plane toroidal field of a single sign. The formation of this slanted symmetry state has not previously been explained. We use radially local 1D vertical shearing box simulations to assess the importance of large-scale MRI channel modes in influencing the formation and morphologies of these wind solutions. We consider only Ohmic resistivity and explore the effect of different magnetizations, with the mid-plane β parameter ranging from 105 to 102. We find that our magnetic winds go through three stages of development: cyclic, transitive, and steady, with the steady wind taking a slanted symmetry profile similar to those observed in local and global simulations. We show that the cycles are driven by periodic excitation of the n = 2 or 3 MRI channel mode coupled with advective eviction, and that the transition to the steady wind is caused by a much more slowly growing n = 1 mode altering the wind structure. Saturation is achieved through a combination of advective damping from the strong wind, and suppression of the instability due to a strong toroidal field. A higher disc magnetization leads to a greater tendency towards, and more rapid settling into the slanted symmetry steady wind, which may have important implications for mass and flux transport processes in protoplanetary discs.

Modelling a paleo valley glacier network using a hybrid model: an assessment with a Stokes ice flow model

Modelling paleo-glacier networks in mountain ranges on the millennial timescales requires ice flow approximations. Hybrid models calculating ice flow by combining vertical shearing (shallow ice approximation) and longitudinal stretching (shallow shelf approximation) have been applied to model paleo-glacier networks on steep terrain, yet their validity has not yet been assessed quantitatively. Moreover, hybrid models consistently yield higher ice thicknesses than Last Glacial Maximum geomorphological reconstructions in the European Alps. Here, we compare results based on the hybrid Parallel Ice Sheet Model (PISM) and the Stokes model Elmer/Ice on the Rhine Glacier, a catchment of the former European Alpine Icefield. For PISM, we also test two magnitudes of flux limitation in a scheme that reduces shearing velocities. We find that the flux limitation typically used in PISM yields significantly reduced shearing speeds and increases ice thicknesses by up to 500 m, partly explaining previous overestimations. However, reducing the ice flux limitation allows the hybrid model to minimize this mismatch and captures sliding speeds, ice thicknesses, ice extent and basal temperatures in close agreement with those obtained with the Stokes model.

Rethinking Superior and Inferior Sacroiliac Shear: A New Approach to Diagnosis and Treatment

The concept of upslipped and downslipped innominate dysfunction has been a part of osteopathic teaching for more than 50 years. In more recent years, the terminology has evolved into superior and inferior innominate shears. The assumption that these somatic dysfunctions result from vertical shearing at the sacroiliac (SI) joint is evaluated in light of new research on sacroiliac motion and stability and the authors’ clinical experiences. The authors propose that the apparent superior or inferior shift of an innominate is better accounted for by sidebending of the innominate at the sacroiliac joint. Altered treatments based on this new understanding are presented.

On the dynamics of turbulence near a free surface

We report on direct numerical simulations to examine the spectral behaviour of turbulence close to and at a flat, stress-free surface. We find, consistent with field measurements near such a free surface, that an inertial-range type of behaviour is obtained for the horizontal components of the velocity at and near the stress-free surface, at horizontal wavelengths for which the vertical velocity is much smaller than the horizontal components. At approximately an integral length scale from the stress-free surface, the flow has adjusted back to more classical isotropic turbulence. The behaviour of the turbulence near the stress-free surface is similar to that observed recently for strongly stratified flows, and we argue that the causes of that behaviour are the same in both flows: the suppression of the large-scale vertical velocity and the allowance of strong vertical shearing of the horizontal velocity leading to a downscale transfer of energy and to the development of the$-5/3$spectra for the horizontal velocities.

Reliability Analysis and Experimental Research on Cutting Tool of Vertical Shearing Machine

The failure cause and failure mode of cutting tool is analyzed based on the reliability analysis on cutting tool of vertical shearing machine. Reliability calculation model is established, and experimental research on cutting tool is operated. The results show that the critical failure mode of cutting tool is electric die grinder .The crucial failure cause is that in the shearing process, the UO2 ceramic in the fuel components is crushed into particles with high hardness, these hard material will lead to tool wear. The reliability of cutting tool is 0.892, which cant achieve the spent fuel reprocessing working shearing machine reliability requirements. The structure and materials of cutting tool must be improved. The parallel distance between the upper surface of cutting tool and the lower surface of the pressing block has to be adjusted.

Data assimilation using a hybrid ice flow model

Hybrid models, or depth-integrated flow models that include the effect of both longitudinal stresses and vertical shearing, are becoming more prevalent in dynamical ice modeling. Under a wide range of conditions they closely approximate the well-known First Order stress balance, yet are of computationally lower dimension, and thus require less intensive resources. Concomitant with the development and use of these models is the need to perform inversions of observed data. Here, an inverse control method is extended to use a hybrid flow model as a forward model. We derive an adjoint of a hybrid model and use it for inversion of ice-stream basal traction from observed surface velocities. A novel aspect of the adjoint derivation is a retention of non-linearities in Glen's flow law. Experiments show that in some cases, including those nonlinearities is advantageous in minimization of the cost function, yielding a more efficient inversion procedure.

Data assimilation using a hybrid ice flow model

Hybrid models, or depth-integrated flow models that include the effect of both longitudinal stresses and vertical shearing, are becoming more prevalent in dynamical ice modeling. Under a wide range of conditions they closely approximate the well-known First Order stress balance, yet are of computationally lower dimension, and thus require less intensive resources. Concomitant with the development and use of these models is the need to perform inversions of observed data. Here, an inverse control method is extended to use a hybrid flow model as a forward model. We derive an adjoint of a hybrid model and use it for inversion of ice-stream basal traction from observed surface velocities. A novel aspect of the adjoint derivation is a retention of non-linearities in Glen's flow law. Experiments show that including those nonlinearities is advantageous in minimization of the cost function, yielding a more efficient inversion procedure.