Development of a high-precision bladder hyperthermic intracavitary chemotherapy device for bladder cancer and pharmacokinetic study

Background Bladder hyperthermic intracavitary chemotherapy (HIVEC) has good effectiveness for bladder cancer, but conventional HIVEC systems lack precision and convenient application. To test the safety of a new HIVEC device (BR-TRG-II-type) in pigs and to perform a preliminary clinical trial in patients with bladder cancer. Methods This device was tested on six pigs to optimize the temperature and time parameters. Then, 165 patients (HIVEC after transurethral resection (TUR), n = 128; or HIVEC, n = 37) treated between December 2006 and December 2016 were recruited. Mitomycin C (MMC) was the chemotherapeutic agent. A serum pharmacokinetic study was performed. The primary endpoints were tumor recurrence, disease-free survival (DFS), and cumulative incidence rate (CIR) during follow-up. The adverse effects were graded. Results The animal experiment showed that 45 °C for 1 h was optimal. HIVEC was successful, with the infusion tube temperature stably controlled at about 45 °C, and outlet tube temperature of about 43 °C in all patients, for three sessions. Serum MMC levels gradually increased during HIVEC and decreased thereafter. The mean DFS was 39 ± 3.21 months (ranging from 8 to 78 months), and the DFS rate was 89.1% during follow-up. No adverse events occurred. Conclusion The use of the BR-TRG-II-type HIVEC device is feasible for the treatment of bladder cancer. Future clinical trials in patients with different stages of bladder cancer will further confirm the clinical usefulness of this device. Trial registration chictr.org.cn: ChiCTR1900022099 (registered on Mar. 252,019). Retrospectively registered.

Effects of Drug Concentration, Rate of Infusion, and Flush Volume on G-CSF Drug Loss When Administered Intravenously

Purpose: This study evaluated factors that affect granulocyte-colony stimulating factor (G-CSF) adsorption in the infusion tube by measuring the G-CSF concentration, rate of G-CSF infusion, and volume of flush solution. Methods: The concentrations of G-CSF in all samples were measured by an enzyme-linked immunosorbent assay (ELISA) using human G-CSF Quantikine® ELISA kits. The concentration of G-CSF, the rate of administration, and the volume of flush solution were studied respectively. The concentration of G-CSF and the rate of administration that had a significantly lower G-CSF percent recovery after the infusion via the infusion set were used for further investigation in the study. All samples were diluted with 5% dextrose in water (D5W) to the final concentration within the standard concentration range. All experiments were performed in triplicate. Results: The concentration of G-CSF that was administered through the infusion tube at 20 µg/mL was a significantly higher G-CSF percent recovery compared with the G-CSF concentrations of 5, 10, and 15 µg/mL. The infusion rate of 15 and 20 mL/h percent recovery of G-CSF adsorption was significantly higher than the infusion rates of 30 and 40 mL/h. The concentration of G-CSF at 15 µg/mL and an infusion rate of 30 mL/h were selected to investigate the flush volumes of D5W on G-CSF adsorption. The D5W flush volume of 40 mL dramatically decreased the G-CSF adsorption with a recovery of 103 ± 1.73%. Conclusion: The G-CSF concentration of 20 µg/mL with an infusion rate of 20 mL/h, using a 40 mL D5W flush, was appropriate for intravenous G-CSF administration.

Design of Arduino-Based Periodic Cycle Drip Monitoring System on the Web

Giving intravenous fluids is very useful to support and accelerate the recovery of the patient's condition during the healing period. Problems in handling can have a negative impact on patients who are currently monitoring intravenous fluids using a manual system. To reduce the adverse effects on patients is to design an arduino-based intravenous fluid monitoring tool. The design of this tool is a way of monitoring that can be done at a distance. This tool aims to provide a warning when the intravenous fluid will run out (Â ± 100 ml) using a weight sensor, detect the drip stop using the ldr sensor and detect the intravenous entering the infusion tube using a photodiode. The value obtained from a sensor will be received by Arduino NodeMCU . Then Arduino will send the value which goes to the database then from the database it will enter the web monitoring. Where the web monitoring is in the nurse's room which monitors intravenous fluids remotely. The data from the heavy sensor has 95% accuracy because the data obtained is not affected by conditions from outside the sensor, while the photodiode and LDR data have 90% accuracy because these two sensors are light sensors that can be affected by light from outside.

One-port vitreous cavity lavage with hybrid 27G infusion and 23G cannula

Purpose: To describe a new surgical technique for performing vitreous cavity lavage. Methods: After a 23G trocar cannula was inserted into the vitreous cavity at the lowest point of the eyeball 3.5 or 4 mm posterior to the limbus, a 27G infusion line with balanced salt solution was attached to the cannula. The infusion tube was partially withdrawn and the vitreous fluid with blood flowed out through the space between the larger lumen of the cannula and the smaller infusion tube. Meanwhile, vitreous cavity was irrigated with fresh balanced salt solution through the infusion line and the intraocular pressure (IOP) was maintained. The vitreous clarity was checked by indirect ophthalmoscopy. Results: A total of 14 eyes of 14 patients with postvitrectomy hemorrhage were treated with the lavage technique. The vision improved and the fundus could be sufficiently viewed next day in all cases. This fluid/fluid exchange procedure was also performed in fluid/air exchange in two cases of unclosed idiopathic macular hole with switching to air infusion instead of balanced salt solution infusion. Conclusion: This minimally invasive technique is a simple, safe, and efficient way of performing postvitrectomy vitreous cavity fluid/fluid or fluid/air exchange.

Stress relaxation of the infusion tube with a pressure sensor

We studied stress relaxation of the infusion tube with a pressure sensor using FEA method. The stress distribution in the tube, the contact pressure on the wall of the pressure sensor, the decay of the reaction force on the wall of the pressure sensor were determined, respectively. Due to the stress relaxation of the infusion tube, the reaction force generated by the tube deformation was decreased by over 75% as compared with the original reaction force in the first several seconds after the infusion tube was set into the pressure sensor.

Prevalence of Subclinical Mastitis in Lactating Cows and Efficacy of Intramammary Infusion Therapy

The aim of the study was to estimate the prevalence of subclinical mastitis (SCM) in lactating cows of Mymensingh and Lakshmipur sadar upazilas and to evaluate the efficacy of intramammary infusion in subclinical mastitis affected cows. A cross-sectional study was carried out on 78 smallholder dairy farms using a pretested questionnaire to collect data from June 2011 to May 2012. Milk samples from 139 lactating cows were screened for SCM by California Mastitis Test. A total of 72 cows was found positive for SCM and treated with the Neomastipra-JR5® intramammary infusion tube (Hipra, Spain). The overall prevalence of subclinical mastitis in lactating cows was 51.8%, of which 51.4% at Mymensingh sadar and 52.2% at Lakshmipur sadar upazilas. The prevalence of subclinical mastitis was significantly increased with age and parity of cows. In left hind quarter, the prevalence of subclinical mastitis was significantly higher (33.1%) than those of other quarters. The efficacy of intramammary infusion with Neomastipra-JR5® in lactating cows was 66.7%.DOI: http://dx.doi.org/10.3329/bjvm.v12i1.20464 Bangl. J. Vet. Med. (2014). 12 (1): 55-61

Immunological deep dermal vasculitis in a cat

In this case report, a 13.5-year-old, neutered, female domestic shorthaired cat with immunological deep dermal vasculitis is described. The patient was presented with lethargy, fever, polydipsia, anorexia and swollen distal limbs. Dermatological examination revealed partial alopecia, pitting edema and painfulness in all distal limbs. Several diagnostic examinations were conducted to confirm the suspected diagnosis and to look for possible triggers of cutaneous vasculitis. Morphological changes that were indicative for deep dermal vasculitis were seen during the histological examination of the skin. The other examinations did not reveal an underlying trigger or cause of the dermal vasculitis. The cat was diagnosed with immunological deep dermal vasculitis. The cat was treated with antibiotics, infusion, tube feeding and prednisolone. Improvement and healing of the dermal symptoms were only noticed after the start of prednisolone therapy.

Research of the Intelligent Medical Infusion Monitoring System

This project is a multi-platform operating system consisting of a upper monitor and some lower position machines. It mainly studies on the detection and control in the process of infusion treatment. Through the infrared detection of the waveform on pulse, using the pulse counting mode, we can measure the number of drops of liquid. We also use a drive motor to control the transfusion drip rate, thus the infusion tube can be closed when necessary and give an alarm. Such a system makes the nursing staff more convenient to operate and can reduce labor intensity and medical accidents.