postcolumn infusion
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Bioanalysis ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 175-189
Author(s):  
Fabio Bachmann ◽  
Lea Blaser ◽  
Manuel Haschke ◽  
Stephan Krähenbühl ◽  
Urs Duthaler

Aim: Metamizole is a frequently used antipyretic and analgesic prodrug, yet its pharmacokinetics has not been thoroughly studied in infants and with coadministered medications. Thus, an LC–MS/MS method was developed to quantify the four major metamizole metabolites in human plasma. Methodology: Pre- and postcolumn infusion was installed to enable robust analyte retention and electrospray ionization following deproteinization of plasma samples. Results: The method was linear (R > 0.996), accurate (93.1–106.0%) and precise (≤12.7%). Mean recovery was more than 91.8% and ion suppression less than 13.1% for all analytes. Pharmacokinetic profiles were reproducible after 4 years at -80°C except for the formylated metabolite (-22.2%). Conclusion: The method fulfilled pertinent criteria of validation guidelines and required only little sample volume. The method therefore qualifies for metamizole analyses in children.


2019 ◽  
Vol 411 (29) ◽  
pp. 7771-7781 ◽  
Author(s):  
Robert Bloch ◽  
Susann-Elisabeth Schütze ◽  
Erik Müller ◽  
Stefan Röder ◽  
Irina Lehmann ◽  
...  

2015 ◽  
Vol 87 (12) ◽  
pp. 5921-5929 ◽  
Author(s):  
Oskar González ◽  
Michael van Vliet ◽  
Carola W. N. Damen ◽  
Frans M. van der Kloet ◽  
Rob J. Vreeken ◽  
...  

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