Efektivitas Media Poster Intervensi Diet Anak Autis Terhadap Peningkatan Pengetahuan Ibu di SLBN Pembina Kupang

Autistic is a very complex developmental disorder in children, which begins to appear before the age of three years. Autistic children have certain food diet so that a mother must have good knowledge about the right foods choices for the children. The increasing of knowledge can be done by various ways, one of them is using poster media. The purpose of this study was to determine the effectiveness of using diet intervention poster media for autistic children to increase the knowledge of mothers in SBLN Pembina Kupang in 2019 year. This study uses One Group Pretest Postest Design and descriptive analysis method. The population are all mothers who have autistic children especialy 16 mothers as a sample. The results shows that using poster media is effective in order to increase mothers knowledge about diet intervention of autistic children (This can be seen from the mean value of the pretest that is 64.38 to 83.75 (it shows that there is an increasing amount 19.37 from early knowledge).

Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated withACTBmutations

Introductory paragraphUntil recently missense germ-line mutations inACTB, encoding the ubiquitously expressed β-cytoplasmic actin (CYA), were exclusively associated with Baraitser-Winter Cerebrofrontofacial syndrome (BWCFF), a complex developmental disorder1,2. Here, we report six patients with previously undescribed heterozygous variants clustered in the 3’-coding region ofACTB. These patients present with clinical features different from BWCFF, including thrombocytopenia, microcephaly, and mild developmental disability. Patient derived cells are morphologically and functionally distinct from controls. Assessment of cytoskeletal constituents identified a discrete filament population altered in these cells, which comprises force generating and transmitting actin binding proteins (ABP) known to be associated with thrombocytopenia3–8.In silicomodelling and molecular dynamics (MD)-simulations support altered interactions between these ABP and mutant β-CYA. Our results describe a new clinical syndrome associated withACTBmutations with a distinct genotype-phenotype correlation, identify a cytoskeletal protein interaction network crucial for thrombopoiesis, and provide support for the hypomorphic nature of these actinopathy mutations.

Metode Glenn Doman Meningkatkan Kemampuan Interaksi Sosial Anak Autis

ABSTRACT Autism is a complex developmental disorder typically arises during the first three years of life, with one of its characteristics being a disorder of social interaction. This study was conducted to determine the effectiveness of Glenn Doman Method on the ability of social interaction of children with autism. This research uses experimental quasi research design with disign approach one group pretest posttest design. The sample used were 15 autistic children with total sampling technique. Data were analyzed by T-dependent test. The result of statistical analysis shows p value 0,000 (0,000

New perspectives in autism spectrum disorders

Autism spectrum disorder, a complex developmental disorder, has been found to be one of the most heritable neuropsychiatric disorders. The next step will be to translate these findings into successful treatments for this disorder.

Das Konzept der «Multiple Complex Developmental Disorder» (MCDD)

Fragestellung: Die «Multiple complex developmental disorder» (MCDD) ist ein wenig bekanntes Störungsbild, das durch Auffälligkeiten in der Emotionsregulation, der sozialen Interaktion und Denkstörungen gekennzeichnet ist. Weder im Klassifikationssystem des ICD-10, noch im DSM-IV kommt diese Diagnose vor. Methodik: In der vorliegenden Arbeit wird eine Übersicht über die diagnostischen Kriterien und den aktuellen Forschungsstand zum Konzept der MCDD gegeben und anhand einer Kasuistik eines 17-jährigen Jugendlichen illustriert. Ergebnis: Das Störungsbild der MCDD weist Überschneidungen zu autistischen Störungen, aber auch zu Störungen aus dem schizophrenen Formenkreis auf. Eine klare Abgrenzung bzw. Zuordnung ist bisher nicht eindeutig möglich. Schlussfolgerungen: Viele Fragen bezüglich des Störungsbildes bleiben offen, weitere Forschung ist hier vonnöten.