The Structural and Morphological Properties of Nanosized Nd(1-x)Sr(x)MnO3 (x = 0; 0.5; 1) Manganite

A set of nanoparticles NdSrMnO3 has been prepared base on sol-gel method. On A site, the nanoparticles were modified by substitution among Nd and Sr. The effect of substitution on A site of sample to the structural and morphological were entirely examined by mean of X-Ray Diffractometer (XRD) and Scanning Electron Microscopy (SEM). From XRD result, it is found that all the sample under investigated show orthorhombic structure indicating that A site substitution does not modify structure. On the other hand, some morphological behavior has been proposed as A site is substituted. The shape and size of sample are significantly different, resulting A site substitution succeed to influenced morphology of nanosized particles.

The Effect of Pregelatinized Taro Starch (Colocasia Esculenta (L.) Schott) Temperature as Filler on Thiamine Hidrochloride Tablet

BACKGROUND: Pregelatinizing is processed to modify structure of starch by heating a certain temperature. Increasing of temperature causes the starch to absorb water and swell quickly in order to obtain a larger particle size. Larger particle size will improve the flowability and compressibility of the granules. Pregelatinized taro starch is used as diluent tablets with wet granulation method. AIM: The objective research was to determine the effect of increasing pregelatinized taro starch temperature as diluent on compressibility and comprimability granule of thiamine hidrochloride compression. METHODS: Pregelatinized taro starch is made by heating the suspension of starch at 50°C, 60°C and 70°C for 10 minutes and then dried. Pregelatinized taro starch is used as a filler of Thiamine Hidrocloride tablets which made by wet granulation method. Test wereperformed for each formula such as quality tests of granules and tablets physical properties and assay. RESULT: Granule compressibility evaluation results show that the formula 1, 2, and 3 qualified with compressibility value is 7.9941 respectively; 6.9929; and 5.9950%. From the results of the one-way ANOVA analysis of the compressibility obtained sig. 0,000 less than 0.05, then there is a significant difference between formula one with the other formulas. CONCLUSION: It shows the difference in temperature affect the compressibility pregelatinized taro starch. The higher the temperature of pregelatinized taro starch, produces tablets with low compressibility.

Predictive fabrication of Ni phosphide embedded in carbon nanofibers as active and stable electrocatalysts

With the combination of first principle calculations and thermodynamics, a predictive fabrication to modify structure and phase was developed.

A Novel PCR Site-Directed Mutagenesis to Modify Structure of Erabutoxin B

Objective: A convenient PCR was used for site-directed mutagenesis to modify structure of proteins or peptides, For function-structure studies of proteins or peptides. Method: the one-step PCR site-directed mutagenesis strategy can introduce mutation of gene through 5/-end of primer, which was applied on peptide Erabutoxin B (EB) to produce three mutants of EB, the activity of mutants was detected by LD50 value of mice. Result: S8Y, R33D, K47R three mutants of EB were obtained by one-step PCR, LD50 of mutants indicated that the activity of mutants decreased in different degree, the activity of R33D was nearly deprived. Conclusion: one-step PCR site-directed mutagenesis was convenien and efficient, it can be applied on restructuring the primary structure of proteins or peptides.