GENETIC FACTORS OF ALCOHOLIC PSYCHOSIS DEVELOPMENT

Известно, что наследственную предрасположенность к алкоголизму на фенотипическом уровне можно изучать с помощью генетических маркеров, возможно отражающих их связь с заболеванием [2, 3]. Многие авторы говорят о существовании биологической предрасположенности к алкоголизму, закрепленной на генетическом уровне [1, 4, 5, 6], однако природа и механизмы наследования при алкогольных психозах до настоящего времени остаются неясными. Цель настоящей работы - поиск маркеров повышенного риска развития алкогольных психозов путем проведения молекулярно-генетического анализа ДНК-маркеров основных ферментов метаболизма этанола It is known that the hereditary predisposition to alcoholism at the phenotypic level can be studied with the help of genetic markers, possibly reflecting their connection with the disease [2, 3]. Many authors say that there is a biological predisposition to alcoholism, fixed at the genetic level [1, 4, 5, 6], However, the nature and mechanisms of inheritance in alcoholic psychoses are still unclear. The aim of this work is to search for markers of increased risk of alcohol psychosis by conducting molecular genetic analysis of DNA markers of the main enzymes of ethanol metabolism.

Prevalence of Delusional Jealousy in Different Psychiatric Disorders

The prevalence of delusional jealousy in 8134 psychiatric in-patients was 1.1%. Delusions of jealousy were most frequent in organic psychoses (7.0%), paranoid disorders (6.7%), alcohol psychosis (5.6%) and schizophrenia (2.5%), while in affective disorder delusions of jealousy could be found in only 0.1%. Because schizophrenia and affective disorder were the most common diagnoses, most patients with delusions of jealousy were schizophrenics. In schizophrenia, women were more likely to suffer from delusional jealousy, while in alcohol psychosis, men were more likely than women to suffer from delusional jealousy.