Ultra-long-life and highly reversible Zn metal anodes enabled by a desolvation and deanionization interface layer

Zinc metal anode in aqueous zinc-ion batteries (AZIBs) is considerably impeded by uncontrollable dendrite growth and intricately water-induced corrosion, leading to low Coulombic efficiency (CE) and limited lifespan. Herein, a...

Introduction

we know to tell many lies that sound like truth,but we know to sing reality, when we will.Hesiod, Theogony 27–28 (trans. M. L. West)Human cooperation and development are underwritten by a practice of information sharing. Given our limited lifespan and point of view, we are dependent on information acquired from others. Our limitations concern both the world and the minds of others. No one can investigate every corner of the universe, or even of their own neighborhood, and we cannot always tell what someone is thinking just by looking at their face. We depend on others to share information with us both about the world and their thoughts. By far, most of the information we acquire from others we acquire from testimony. Language is our best tool for sharing information. This system of using language to overcome our cognitive limitations relies fundamentally on sincerity. In the most ordinary case ...

Andermann Syndrome in a Pakistani Family Caused by a Novel Mutation in SLC12A6

Agenesis of the corpus callosum with peripheral neuropathy (ACCPN) or Andermann syndrome is an autosomal recessive condition caused by mutations in SLC12A6. The neurodegenerative features are characterized primarily by severe and progressive polyneuropathy, with eventual loss of ambulation and limited lifespan. We report two siblings with Andermann syndrome from a consanguineous Pakistani family with severe global developmental delays, sensory-motor polyneuropathy, and complete agenesis of the corpus callosum, associated with a homozygous c.745+2T>A mutation in SLC12A6. This sequence change is predicted to inactivate the donor splice site and abolish correct splicing of intron 6, yielding an abnormally truncated protein. This is the first report of Andermann syndrome in patients of Pakistani origin, which supports the pan-ethnic incidence of this condition.

Exploring Current Trends of Energy Harvesting

There are numerous forms of energy that can gratify the needs of computing, these energies include solar, thermal, mechanical, wind, acoustic, and wave for different devices and applications. With ubiquitous computing requirements for self-powered devices such as MEMS (Micro-electromechanical systems) and these devices have narrow capacity of finite power sources and it is needed that these systems are needed to be supplied with energy for the lifetime of the system. Mostly Batteries are the main source of energy for many of these mobile systems, embedded systems and remote system applications. There is a requirement for Energy harvesting which is a method of extracting energy from the nearby environment called Environmental energy which can be used as supernumerary to electrochemical battery. Studies are being conducted to harvest energy from solar, wind, thermal, tidal and other mechanical sources which have limited lifespan. This paper serves as a study to identify various sources of energy available for harvesting centered on various technical papers available and present the work carried out by investigators in identifying them.

A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization

Short, repetitive, G-rich telomeric sequences are synthesized by telomerase, a ribonucleoprotein consisting of telomerase reverse transcriptase (TERT) and an integrally associated RNA. Human TERT (hTERT) can repetitively reverse transcribe its RNA template, acting processively to add multiple telomeric repeats onto the same substrate. We investigated whether certain threshold levels of telomerase activity and processivity are required to maintain telomere function and immortalize human cells with limited lifespan. We assessed hTERT variants with mutations in motifs implicated in processivity and interaction with DNA, namely the insertion in fingers domain (V791Y), and the E primer grip motif (W930F). hTERT-W930F and hTERT-V791Y reconstitute reduced levels of DNA synthesis and processivity compared with wild-type telomerase. Of interest, hTERT-W930F is more defective in translocation than hTERT-V791Y. Nonetheless, hTERT-W930F, but not hTERT-V791Y, immortalizes limited-lifespan human cells. Both hTERT-W930F– and hTERT-V791Y–expressing cells harbor short telomeres, measured as signal free ends (SFEs), yet SFEs persist only in hTERT-V791Y cells, which undergo apoptosis, likely as a consequence of a defect in recruitment of hTERT-V791Y to telomeres. Our study is the first to demonstrate that low levels of DNA synthesis—on the order of 20% of wild-type telomerase levels—and extension of as few as three telomeric repeats are sufficient to maintain functional telomeres and immortalize limited-lifespan human cells.

Why do we need to age?

A key question remains: why do multicellular organisms have a limited lifespan? The aging process is considered to be a decline of keeping the molecular, cellular and organ structure and interactions upright. It is hypothesized here that an evolutionary force has actively selected for limited lifespan and prior to that there is the process of aging. Many theories exist, including the endocrine theory of aging and reproduction-based aging. Here, a hypothesis is deduced for the driving force of the evolution of aging and lifespan limitation.

Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia

Many cancers arise in a tissue stem cell, and cell differentiation is impaired resulting in an accumulation of immature cells. The introduction of all-trans retinoic acid (ATRA) in 1987 to treat acute promyelocytic leukemia (APL), a rare subtype of acute myeloid leukemia (AML), pioneered a new approach to obtain remission in malignancies by restoring the terminal maturation of leukemia cells resulting in these cells having a limited lifespan. Differentiation therapy also offers the prospect of a less aggressive treatment by virtue of attenuated growth of leukemia cells coupled to limited damage to normal cells. The success of ATRA in differentiation therapy of APL is well known. However, ATRA does not work in non-APL AML. Here we examine some of the molecular pathways towards new retinoid-based differentiation therapy of non-APL AML. Prospects include modulation of the epigenetic status of ATRA-insensitive AML cells, agents that influence intracellular signalling events that are provoked by ATRA, and the use of novel synthetic retinoids.

A MODEL FOR THE MAINTENANCE OF OLD AIRCRAFT

This paper presents an approach to the development of condition-based maintenance of aircraft to improve aircraft maintenance in the limits and conditions of small countries and in accordance with global technological achievements. For the aircraft that were under a limited lifespan maintenance concept, a new condition-based maintenance model is developed. This model applies a technical diagnostic method that brought us to decreasing numbers of failures in the ageing period of those technical systems and at the same time decreases the time when it is out of use and lowers maintenance expenses. An analysis based on this model showed its applicability, preservation of operational readiness, and potential for decreasing the cost of aircraft maintenance.