fibrillar network
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2021 ◽  
Author(s):  
Keel Yong Lee ◽  
Huong Nguyen ◽  
Agustina Setiawati ◽  
So-Jung Nam ◽  
Minyoung Kim ◽  
...  

Abstract The unfolded states of fibronectin (FN) subsequently induce the formation of the extracellular matrix (ECM) fibrillar network, which is necessary to generate new substitutive tissues. Here, we demonstrate that negatively charged small unilamellar vesicles (SUVs) qualify as candidates for FN delivery due to their remarkable effects on the autonomous binding and unfolding of FN, which leads to increased tissue regeneration. In vitro experiments revealed that the FN-SUV complex remarkably increased the attachment, differentiation, and migration of fibroblasts. The potential utilization of this complex in vivo to treat inflammatory colon diseases is also described based on results obtained for ameliorated conditions in rats with ulcerative colitis (UC) that had been treated with the FN-SUV complex. Our findings provide a new ECM-delivery platform for ECM-based therapeutic applications and suggest that properly designed SUVs could be an unprecedented FN-delivery system that is highly effective in treating UC and other diseases.


2021 ◽  
Author(s):  
K Saleem ◽  
Pritha Dey ◽  
Charitha Sumeet ◽  
Mayur Bajaj ◽  
Y Geetika ◽  
...  

AbstractThis study attempts to identify the significant role played by the secondary structure of collagen-derived peptides that are involved in lipid peroxide quenching in food products. Collagen was extracted from the skin of Perch and swim bladder of Rohu at 45-78% efficiency. It was identified as type-I based on a high molecular weight (110kDa) and its ion-exchange elution profile. The collagen samples were enzymatically hydrolyzed and collagen hydrolysate (CH) was extracted with an efficiency of 0.67-0.74g/g of collagen. The CH samples displayed a molecular weight in the range of 8.2-9.7kDa and exhibited a higher abundance of charges resulting in higher solubility. The structural studies revealed that the CH peptides existed in polyproline-II helix and formed a mimic-triple helix in a wide range of pH. In neutral and alkaline pH, the mimic helices joined to form a hierarchical quasi-fibrillar network that was smaller than collagen fibrils but also more dynamic. The CH exhibited >95% degradation in 15h through simulated digestion. The CH were able to decrease peroxide formation by 84.5-98.9% in commercially available cod liver and almond oil and increased the shelf life of soya bean oil by a factor of 5 after 6 months of storage. The addition of CH to cultured cells quenched peroxide ions generated in situ and decreased stressor activity by a factor of 12. The reason behind the high efficacy of CH was deciphered to be the proximal charge stabilization by the quasi-fibrillar network, which allowed efficient peroxide quenching and long-term stability.


Langmuir ◽  
2020 ◽  
Vol 36 (44) ◽  
pp. 13342-13355
Author(s):  
Koduvayur A. Ramya ◽  
Samala Murali Mohan Reddy ◽  
Ganesh Shanmugam ◽  
Abhijit P. Deshpande

2020 ◽  
Vol 53 (20) ◽  
pp. 8974-8981
Author(s):  
Mehak Jain ◽  
Jyoti R. Seth ◽  
Lohitha R. Hegde ◽  
Kamendra P. Sharma

2020 ◽  
Vol 56 (92) ◽  
pp. 14487-14490
Author(s):  
Rosa Martí-Centelles ◽  
Jenifer Rubio-Magnieto ◽  
Beatriu Escuder

A minimalistic multicomponent cell mimetic is constructed from a catalytic low molecular weight fibrillar network and a polymersome compartment.


2020 ◽  
Vol 8 (11) ◽  
pp. 3748-3757
Author(s):  
Soumyajit Hazra ◽  
Arnab Shit ◽  
Radhakanta Ghosh ◽  
Kingshuk Basu ◽  
Arindam Banerjee ◽  
...  

The morphology of a cationic polythiophene changes from core–shell to a mixed fibrillar network with black spots, quenching of the PL-intensity and an enhanced photo switching property on addition of peptide appended perylene bisimide.


RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4755-4762
Author(s):  
Braja Gopal Bag ◽  
Abir Chandan Barai

Stigmasterol extracted from the leaves of Roscoea purpurea spontaneously self-assembled in liquids yielding a fibrillar network and gel.


Author(s):  
Carla Arnau-del-Valle ◽  
Carles Felip-León ◽  
César A. Angulo-Pachón ◽  
Francisco Galindo ◽  
Juan F. Miravet

2019 ◽  
Vol 253 ◽  
pp. 106231 ◽  
Author(s):  
Vincenzo Martorana ◽  
Samuele Raccosta ◽  
Daniela Giacomazza ◽  
Lorena Anna Ditta ◽  
Rosina Noto ◽  
...  

2019 ◽  
Vol 31 (13) ◽  
pp. 4817-4830 ◽  
Author(s):  
Ghazi Ben Messaoud ◽  
Patrick Le Griel ◽  
Daniel Hermida-Merino ◽  
Sophie L. K. W. Roelants ◽  
Wim Soetaert ◽  
...  

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