Central adverse drug reactions of NSAIDs

Non-steroidal anti-inflammatory drugs (NSAIDs) is a group of drugs used for analgesia, antinflammatory, antipyretical properties, and antiplatelet effects. NSAIDs are widely used in the treatment of osteoarthritis, musculoskeletal pain, gout and other pathological conditions, however, their use is associated with the risk of developing adverse drug reactions, including serious and fatal ones, for example, gastrointestinal bleeding, or myocardial infarction and stroke. Many NSAIDs can also cross the blood-brain barrier and cause central adverse drug reactions that can be mistaken by practical health care professionals for the manifestation of a new pathologies or insufficient effectiveness of treatment of an existing disease, but not with the use of NSAIDs, that may lead to errors in treatment tactics, additional prescription of drugs and an increased risk of complications. The purpose of this article is to inform practical health care professionals about the potential risks of central adverse drug reactions (including psychiatric ones) of NSAIDs, and thus, to increase the effectiveness and safety of therapy.

Importance of herpes simplex virus in development of infertility in married couples

The article considers the role of herpes simplex viruses of 1st, 2nd types in the development of reproductive disorders in married couples. The clinical example shows the difficulties of diagnosis, possible errors in treatment approaches, and the lack of results from the use of artificial insemination methods in the presence of persistent herpetic infection. Prolonged antiviral therapy led to the onset of pregnancy and the birth of a child.

Endometriosis. Case report

Extragenital endometriosis (EGE) is the rarest variant of endometrioid disease. This is a process in which a benign growth of tissue similar to the endometrium in morphological and functional properties occurs outside the uterine cavity. The manifestation of the disease has an erased course characteristic of other diseases and patients are more likely to end up in non-core departments, which is accompanied by errors in treatment tactics. According to the data of T.V. Dresvyanskaya et al., the frequency of EGE is 68% of the number of all cases of detection of endometrioid disease. The article presents a case of successful surgical treatment of EGE of rare localization.

Gallbladder polyps: diagnosis and treatment tactics (literature review)

Gallbladder polyps are an elevation of the mucous membrane that protrudes into the lumen of the gallbladder cavity. Pathology, according to world literature, occurs with a frequency of 0.3% to 13.8%. Currently, the diagnosis of polypoid formations of the gallbladder is based on the routine use of ultrasound, without further clarifying research, which often leads to errors in treatment tactics. In the domestic literature, there are very few studies on this topic, despite the relevance of this area.

Differential diagnosis of gallbladder opisthorchiasis and cholelithiasis in a teenager

Relevance. Parasitic invasions of the biliary tract, such as opisthorchiasis, are one of the significant causes of the formation of pigment calculi in the gallbladder, which is known in territories endemic for these diseases. However, visualization of the dynamics of the development of the pathological process using ultrasonography does not allow differentiating gall stones with a high degree of accuracy from the stages of development of the feline fluke. In the absence of an epidemiological history, this invasion can proceed under the guise of gallstone disease, which leads to an unjustified surgical intervention with the removal of a practically healthy gallbladder from a child. Before surgery, differentiation of calculi in the gallbladder from the stage of opisthorchiasis will significantly improve the quality of life of the child.The aim of the study was to demonstrate a clinical case of opisthorchiasis invasion in a child in a non-endemic territory, proceeding under the guise of cholelithiasis.Material and methods: the case history of a 17‑year-old girl with opistochiasis invasion is presented.Discussion. Parasitic invasion (opisthorchiasis) caused the formation of «calculi» of the gallbladder in the child. Not every hyperechoic formation of the gallbladder with the presence of a sound track is a «calculus». Timely diagnosis of the cause of cholelithiasis is important, as well as timely treatment of parasitic invasion to avoid relapse of the disease and errors in treatment, including surgical treatment.

Metode Terintegrasi sebagai Edukasi Paling Tepat oleh Dokter kepada Pasien Lansia

Communication is an ability that must be owned by a doctor, with this ability doctors can obtain information from a patient, in addition to delivering education, a doctor must have a good communication skills. In dealing with elderly patients, doctors must be able to determine the method to be used, because the elderly’s ability to understand something new is different from the patient in general. With this difference in ability, elderly patients also have to get different communication methods. The purpose of this study was to determine which educational method was the most appropriate for doctors to use for elderly patients regarding the ability of the elderly. The method used in this study is a qualitative method with analytical descriptive, where data is collected by observing, interviewing, and comparing with similar journals that have ever existed. From the data collected, it will be analyzed and obtained in descriptive form. The results of the research conducted are that the most appropriate education for elderly patients is an integrated method, in which this method combines implicit methods and explicit methods. With the results of this study, it is expected that doctors can use the right educational method for elderly patients thereby reducing errors in treatment.