Predicting Melanoma Staging using Targeted RNA Sequencing data using Machine Learning.

The aim of this study is to use machine learning to predict tumor staging and metastasis in melanoma with differentially expressed genes. Machine has been used in different clinical setting to predict different outcomes. However, it has not been used to look at predicting the diagnostic aspect of tumor staging. We used the TCGA RNA-Sequencing data on melanomas to predict tumor staging nodal and/or metastasis using deep neural networks (DNN) and random forest classifier (RF). Results: We were able to predict tumor staging (lower vs higher stage, i.e. Tis / T1 / T2 vs T3 and higher), nodal metastasis and combined nodal or distant metastasis in patients with melanomas with high accuracies. However, we need to further validate these results.

Factors determining the level of high qualification and sports achievements in long-term training of female tennis players (diagnostic aspect)

Table tennis is a complex analytical sport with versatile technique, various specific solutions, which has long outgrown a period of mass enthusiasm. For athletes to achieve sports results, general physical, special and psychological training is now necessary. Modern requirements to the level of special, technical, tactical and physical training of female athletes, to the entire system of their training are extremely high. In this regard, the importance of specialized factors in the sports training of female tennis players increases significantly. In the long-term training of the highly qualified female tennis players, a number of important stages is provided for, which in their structure have specific tasks and a meaningful orientation of their implementation. The task of implementing classification standards of the competitive activity of female tennis players is a complex training process that should be carried out not only taking into account general psychological and pedagogical laws, but also specific scientifically based methods and techniques of pedagogical influence, the organization of this type of activity and an individual approach.

Anti-innovation barriers in the professional activity of university lecturers in Ukraine and ways to overcome them: diagnostic aspect

The article presents the analysis of anti-innovation barriers in the professional activity of lecturers in Ukraine and outlines the ways to overcome this phenomenon. For this reason the discussions of domestic and foreign scientists on the given problem are introduced; the scientific bases of innovative activity of pedagogues are defined, its essential characteristics are outlined; the reasons for the lecturers’ and teachers’ of general secondary education resistance to pedagogical innovation are identified. The authors represent an experimental scientific study of the problem in the practical activities of educational institutions in Ukraine. The subjects of the experiment were lecturers, students and school teachers in different regions of Ukraine. The pedagogical experiment conducted at the diagnostic level allowed to identify the main problems of educational activities in the field of pedagogical innovation and to propose an original method aimed at overcoming the reasons that hinder the introduction of innovative principles into the educational process of higher educational institutions.

Exploratory laparotomy in chronic non-specific pain abdomen in lieu of therapeutic and diagnostic aspect: a prospective non randomized trial on 40 patients

Background: A significant number of patients attending surgical or medical out doors and clinics of prominent doctors, we find them having thick record files visiting from one doctor to another. Majority of such patients diagnosis remain “chronic pain abdomen” in spite of all possible investigations and all sort of recent and ancient medicines. Aim of this study is to analyze the diagnosis and therapeutic value of exploratory laparotomy.Methods: A prospective non randomized study was done on 40 patients who follows our strict criteria and in spite of all relevant investigations’ diagnosis remain chronic nonspecific pain abdomen (CNSPA). Exploratory laparotomy was done and findings were recorded and analyzed to see its diagnostic and therapeutic value.Results: Patients of appendicular (maximum 27.5%) and tubercular disease present within one year of first appearance of pain whereas those having bands and adhesions after two years. Overall exploratory laparotomy was diagnostic and therapeutic in 80% patients.Conclusions: In selected patients of CNSPA exploratory laparotomy is therapeutic in 87.5% and diagnostic in 92.5% patients.

STUDY THE EFFECT OF EXCESSIVE SOIL CONTACT ON SOLES OF FEET IN DIFFERENT DEHA PRAKRUTI VOLUNTEERS WITH REFERENCE TO RUKSHADI VATA GUNA

Ayurveda is an ancient system of medicine documented and practiced in India since time immemorial. According to this system, an individual’s Prakruti (basic constitution) to a large extent, determines predisposition and prognosis to diseases as well as therapy and lifestyle regime. Therefore, Prakruti pariksha plays an important role in examination of patient and diagnostic aspect hence can influences its prevention also. In Ayurveda excessive soil contact is main cause of padadari in explained under sushrut samhita. So, one needs to understand that there should be some correlation between excessive soil contact and padadari i.e cracked feet.