Experimentally Induced Cerebral Cystic Echinococcosis in Rats: A Suitable Animal Model for Cerebral Echinococcosis

Background: Echinococcus granulosus is a worldwide zoonotic cestode that lives mainly in the intestine of dog as definitive host. Its larval stage infects intermediate hosts and forms hydatid cysts mainly in the liver and lungs tissues and less other organs such as brain, eye and bone. In the experimental models, inoculation of protoscoleces into the peritoneum, thoracic cavity, subcutaneous and cerebrum produces hydatid cysts. Experimental echinococcosis in the animal models provides a good opportunity for study of the parasite-host relationship, different transmission ways of infection in the intermediate hosts and effect of new drugs. Methods: The present study was conducted in the Veterinary School, Shahid Bahonar University of Kerman, Kerman, Iran in 2018. In this study, cerebral hydatidosis was investigated in 6 female Wistar rats weighing (200±20 gr). For this purpose, protoscoleces were collected from hydatid cysts of infected sheep liver. Overall, 300 protoscolices were injected directly in the lateral ventricle by an insulin syringe through the implanted cannula. Results: After 4 months of inoculation, multiple thin-walled, transparent hydatid cysts were observed in the rat skull. All cysts were infertile. The cysts were localized prominently on the cerebral cortex and lesser in the parenchyma and ventricles. The cyst walls consisted of three layers consist of the outer layer (fibrous capsule), two parasitic layers and the endocyst layer (germinal layer). The cyst was surrounded by the inflammatory cells consist of lymphocytes, plasma cells and macrophages. Conclusion: To the best of our knowledge, this research is the first experimental cerebral hydatidosis arisen from larval stage of Echinococcus granulosus in the animal model.

A rare case of cerebral hydatidosis caused by a G1 genotype of Echinococcus granulosus in a cow from Iran

Hydatidosis is a medically and veterinary important parasitic disease that is endemic in many parts of the world. Unilocular hydatid cysts may develop in almost any part of the body. Up to 70% of hydatid cysts are located in the liver, followed by 25% in the lungs. Cerebral hydatidosis is an uncommon manifestation of the disease, occurring in less than 1/1000 infected hosts, yet diagnosis does pose a problem. We have reported an exceptionally rare case of cerebral hydatidosis in cattle. This is the first report to describe the characteristic pathological features of the cerebral hydatidosis in cattle caused by the G1 genotype of Echinococcus granulosus. Genotypic analysis was performed on a hydatid cyst from a cow originating from southern Iran, based on the sequence analysis of the cox1 mitochondrial gene.

Multiple recurrent cerebral hydatidosis: A case report with review of literature

Echinococcisis is an emerging zoonotic parasitic disease worldwide and is a significant health burden among developing nations. Cystic hydatidosis is more commonly found in lungs and liver but rarely cerebral involvement can occur. Multiple hydatid cysts of brain are uncommon and may be wither primary or secondary. Hydatid cyst shoud be considered as a differential diagnosis for cystic lesions of the brain. Here we are reporting a 8 year old boy with multiple cerebral hydatid cysts recurring within three months after surgical rupture of a primary large cerebral hydatid cyst.Asian Journal of Medical Sciences Vol.7(1) 2015 105-107

Intracranial intraosseous hydatid cyst

Cerebral hydatidosis accounts for approximately 1 to 3% of all cases of hydatid disease. Generally, cerebral hydatid cysts are single lesions located in the watershed of the middle cerebral artery. Primary intracranial extracerebral hydatid cysts are extremely rare. Only 2% of hydatid cysts are localized in the skeleton, and of these 3 to 4% are found in the skull. The authors describe the case of a 10-year-old boy who was admitted to their clinic with headache and unilateral focal epileptic seizures. Computerized tomography scanning revealed a right parietal intraosseous hydatid cyst. A case of cranial intraosseous hydatid disease is presented, and the differential diagnosis and treatment are discussed in the light of literature.