An unusual case of ectopic abdominal pregnancy in a bitch - a case report

There are only a few reported cases of abdominal ectopic pregnancy and consequential foetal mummification in dogs. The majority of the described cases indicate that this condition may exist for a prolonged period of time without any manifestation of illness. Therefore, sudden signs of abdominal distension, abdominal pain, episodes of epileptiform seizures, dark diarrhoea and lethargy, as were observed in the present case, are not likely to be considered as symptoms of an abdominal ectopic pregnancy. Furthermore, to the best of our knowledge, this is the first report of an eight-year long abdominal pregnancy in an ovariohysterectomised bitch. We present the clinical, laboratory, radiological and intraoperative findings, and the medical and surgical therapy for an abdominal ectopic pregnancy in a 14 year old Miniature Pinscher bitch, ovariohysterectomised eight years previously.

Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats

The study of the role of neurotransmitter systems in the pathogenesis of epilepsy is one of the priorities of epileptology. New data on the functions of free neurotransmitter-like amino acid in the central nervous system are of the greatest importance and determine the prospects for the development of novel effective anticonvulsants. It is widely believed in clinical medicine that epilepsy has distinct gender characteristics. The aim of this study was to investigate the gender peculiarities in the content of neurotransmitter amino acids in the brain of Krushinsky-Molodkina (KM) rats, which were used as model organisms for the study of genetically induced audiogenic epilepsy. The content of Asp, Glu, GABA, Gly, and Tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (HPLC) in intact KM rats, KM rats exposed to a series of epileptiform seizures, and Wistar rats (control group). Both the Wistar and KM rats had gender distinctions in the distribution of free amino acids among the investigated brain parts. The audiogenic epilepsy was characterized by smoothing gender differences as well as differences between the concentrations of free amino acids in the cortex and medulla oblongata, specific for Wistar rats. The changes observed in male rats after the set of seizures included the increase in GABA concentration and a decrease in the Gly level in all investigated brain parts, as well as the decrease of the Tau content in the cortex and hippocampus. At the same time, the Glu content in cortex increased, while the Asp level decreased. After 6 days of audiogenic stimulations the female KM rats demonstrated the increase in the Glu level in all investigated brain parts, the increase in Gly and Asp levels in hippocampus, and no changes in the GABA content. Thus, after the set of epileptiform seizures the KM rats achieved a new steady state of the studied amino acids pool, which differed in males and females. In this case, gender differences significantly changed after the seizures.

Psychogenic Non-Epileptic Seizures: A Case Report

Psychogenic non-epileptiform seizures (PNES) are a common condition that affects over 400,000 individuals within the United States. PNES are a challenging entity in modern medicine, for they are located at the interface between neurology and psychiatry regarding clinical presentation and pathophysiology. The experiences and symptomatology of the patients resemble those associated with epileptic seizure activity, however many patients present with co-occurring psychiatric comorbidity. A combination of video-electroencephalography and a concise, welldocumented clinical history of the event helps in a definitive clinical diagnosis of PNES. Measuring the levels of serum prolactin may prove useful as an adjunctive laboratory test in diagnosing PNES. Management of PNES involves prompt patient education regarding the condition and treating the psychiatric comorbidity as well. A combined approach of both psychotherapeutic and pharmacological interventions helps in the optimal treatment of PNES.